Myxoid Liposarcoma Treatment

Health Q&A
68 year old Male

Detected BONE MARROW (Multiple Mylomia), in 2016.(Near spinal cord) Blood Test indicated 25% Plasma Cell, in 2016. So far done this Tests 16 times, till last month. Now it is 1 %. Should I take that now I have been cured almost of Multiple Myloma. No medicine since last 6 months. ( Before that took THALIX-100 : 1 Tablet /day.) Thanks

Conventional prostatic adenocarcinoma

What should be the next treatment? How can we treat this Conventional prostatic adenocarcinoma with neuroendocrine differentiation and an extensive small cell type? He has aged alot , psa is 1.1, Intense FDG uptake noted in peripheral zone of right lobe of enlarged prostate (measures 5.0x4.3 cm); SUVmax 10.9 FDG avid bilateral external iliac, left obturator nodes; ~ 3.1x2.5 cm, SUVmax 9.5 FDG avid few bilateral hilar, subcarinal, paratracheal, prevascular nodes (largest measures 1.8x0.9 cm; SUVmax 8.5), few of them demonstrating hyperattenuation of NCCT thorax: favours the granulomatous etiology. No other significant adenopathy noted FDG avid extensive lytic and marrow lesions (few with associated soft tissue; Intraspinal extension at the level of few dorsal-lumbar vertebrae and sacrum) are noted involving axial and proximal appendicular skeleton; SUVmax 9.5. Variable FDG avid varying sized hypodense lesions in both lobes of liver; largest measures ~ 2.5x3.0 cm (segment V), SUVmax 14.5

Tnbc with pik3

Hi, My mother got diagnosed with upfront mbc on nov 2023 and that time it was er pr +ve and her2 negative so taxol given for 6 cycle then palbociclib with letro went for nearly 1.7 yrs then progression and did re biopsy then its changed to triple negative and also did gene and ngs test. Gene test came negative but ngs test showed pik3ca mutation and pd L1 also came negative. Then docetaxol and carboplaton chemo went for 6 cycle then few days back pet scan done but no response and its progressed again on liver. Now doctor suggested alpelisib and fulvestrant and started on it. Am really worried will alpelisib works on this tnbc? And how long can be managed and also aide effects etc.

CML patient having alcoholic addiction

I have been a CML patient since 2016 and have had undetectable reports since 2023. Since last year due to family and personal issues. I became alcohol sober and can't skip any day. I was told by a doctor friend that Neltrexone 50mg will help me to stop alcohol. But I am afraid whether it will interact with my CML medicine. Please advise I am living a very bad life. Please help me answer.

Intramucosal andenocarcinoma

Good evening Doctor. I had intramucosal adenocarcinoma of the rectum about 9 years ago, arising from a tubulovillous adenoma (2 × 2 cm), moderately differentiated, with no invasion beyond the muscularis mucosa. Only polypectomy was done, and no further treatment was required. The report showed MSI negative / MMR proficient. At that time MRI pelvis and CT scan were normal, and post-polypectomy site biopsy showed no dysplasia or malignancy. Follow-up done regularly: • Colonoscopy – about 10 times, all normal (last on 12 November 2025) • USG whole abdomen – 10 times, all normal • Blood tests – about 6 times, normal • Chest X-ray (PA) – 4 times, normal Kindly advise the appropriate interval for future surveillance colonoscopy. Also, if a new polyp appears in future, would it necessarily be malignant in my case, or usually benign? . Kindly send your advice by SMS when convenient. Thank you.

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Doctors
Dr. William  Hicks - Internal Medicine
Dr. William Hicks Internal Medicine (Medical School, Fellowship in Neurology - Vascular, Residency in Neurology, Internship, Transitional Year, Medical degree, DO, Internship) 52 years experience Ohio State Brain and Spine Hospital
Weinland Park, COLUMBUS
Dr. JAMES G SIVARD - General Surgeon
Dr. JAMES G SIVARD General Surgeon (Medical School, Internship, Residency) 47 years experience OhioHealth Doctors Hospital
Forest Park West, COLUMBUS
Dr. Timothy  Moore - Internal Medicine
Dr. Timothy Moore Internal Medicine (Residency, Medical School, B.S., Internship-Internal Medicine, Residency in Internal Medicine, Clinical Fellowship in Hematology and Medical Oncology) 45 years experience Select Specialty Hospital - Columbus
Short North, COLUMBUS
Dr. Jeffrey  Zangmeister - Internal Medicine
Dr. Jeffrey Zangmeister Internal Medicine (Fellowship, Residency, Medical School, Internship, Residency in Internal Medicine, Clinical Fellowship in Hematology and Medical Oncology, Medical Education, Fellowship 2, Residency - ID, Class of 1981) 45 years experience Zangmeister Cancer Center
Columbus 43222, COLUMBUS
Dr. Michael A. Caligiuri - Internal Medicine
Dr. Michael A. Caligiuri Internal Medicine (Medical School, Residency, Summa Cum Laude, Phi Beta Kappa, Master’s Degree in Physiology, Medical degree, DO, B.A., M.A., M.D., Undergraduate Degree in Humanities and Health Science) 43 years experience The James Cancer Center
Columbus 43210, COLUMBUS