Hello Doctor, my mother has ovarian cancer and has completed 4 cycles of neoadjuvant chemotherapy with very good response (CA-125 reduced from 273 to 11). Her treating team is now planning interval cytoreductive surgery with HIPEC.
We would like to take an expert opinion specifically regarding whether HIPEC is truly necessary/beneficial in her case, considering the additional recovery burden and cost. Could you please help us in deciding if HIPEC would be necessary and effective ?
Thank you.
Hello Doctor,
Seeking your opinion regarding a 71-year-old patient diagnosed with NSCLC favor squamous cell carcinoma (P40 diffuse positive, TTF1 negative) involving the right upper lobe. PET-CT shows a spiculated RUL lesion approx. 3.0 × 4.7 × 4.0 cm with SUV max 16.58. Mildly FDG-avid hilar/paratracheal nodes (SUV ~4.2) with some calcification noted. EBUS/TBNA from stations 4R, 7 and 11L showed no evidence of malignancy. Current staging documented as cT2bN1M0 (Stage IIB). Proposed plan is neoadjuvant chemotherapy followed by reassessment for surgery.
Would appreciate guidance on:
1. Whether chemo + surgery appears the optimal curative-intent approach in this case.
2. Whether adding immunotherapy to neoadjuvant chemotherapy would significantly improve outcomes.
3. Whether current imaging/EBUS findings sufficiently support N1 staging or need further nodal evaluation.
Thank you.
I was undergoing IVF treatment which started in 2024 as part of my pre-IVF assessment. I was given a diagnostics hysteroscopy that revealed that I had hyperplasia without atypia in 2024. I don't remember that my doctor was concerned during that time and the only treatment that I was given was Crina 10 for 10 days for my spotting in leutal phase. Now I this year. I am due for an embryo transfer and again, my doctor was examining my uterus and she mentioned that I have polyps in my uterus and when I referred to my past report just to see that what it said in 2024 i found about the hyperplasia and when I did some googling, I understood that this is a serious condition that should have been taken care. I am due for another hysteroscopy but I am scared as this was ignored. Reports from 2024 biopsy attached
Hi my mother had her routine mammogram revealed 6.5 cm hamartoma in left breast without any symptoms. Is that dangerous, what is the treatment for that??
What should be the next treatment? How can we treat this Conventional prostatic adenocarcinoma with neuroendocrine differentiation and an extensive small cell type? He has aged alot , psa is 1.1, Intense FDG uptake noted in peripheral zone of right lobe of enlarged prostate (measures 5.0x4.3 cm);
SUVmax 10.9
FDG avid bilateral external iliac, left obturator nodes; ~ 3.1x2.5 cm, SUVmax 9.5
FDG avid few bilateral hilar, subcarinal, paratracheal, prevascular nodes (largest measures 1.8x0.9 cm;
SUVmax 8.5), few of them demonstrating hyperattenuation of NCCT thorax: favours the granulomatous etiology.
No other significant adenopathy noted
FDG avid extensive lytic and marrow lesions (few with associated soft tissue; Intraspinal extension at the level of few dorsal-lumbar vertebrae and sacrum) are noted involving axial and proximal appendicular skeleton; SUVmax 9.5.
Variable FDG avid varying sized hypodense lesions in both lobes of liver; largest measures ~ 2.5x3.0 cm (segment V), SUVmax 14.5
