What should be the next treatment? How can we treat this Conventional prostatic adenocarcinoma with neuroendocrine differentiation and an extensive small cell type? He has aged alot , psa is 1.1, Intense FDG uptake noted in peripheral zone of right lobe of enlarged prostate (measures 5.0x4.3 cm);
SUVmax 10.9
FDG avid bilateral external iliac, left obturator nodes; ~ 3.1x2.5 cm, SUVmax 9.5
FDG avid few bilateral hilar, subcarinal, paratracheal, prevascular nodes (largest measures 1.8x0.9 cm;
SUVmax 8.5), few of them demonstrating hyperattenuation of NCCT thorax: favours the granulomatous etiology.
No other significant adenopathy noted
FDG avid extensive lytic and marrow lesions (few with associated soft tissue; Intraspinal extension at the level of few dorsal-lumbar vertebrae and sacrum) are noted involving axial and proximal appendicular skeleton; SUVmax 9.5.
Variable FDG avid varying sized hypodense lesions in both lobes of liver; largest measures ~ 2.5x3.0 cm (segment V), SUVmax 14.5
I have checked everything except for colonoscopy, all are normal according to doctors, apart from grade 1 fatty liver, it is over 3 months I don't somke and drink, all CA markers are normal, still my fear of cancer keeps coming back, please suggest what to do
My mother was diagnosed upfront as metastatic breast cancer on Nov 2023. At that time it was ER PR positive Her2 negative so first treatment was taxol chemo 6 cycle and then tumor reduction and given palbociclib tablet with letrozole for an year and half hr then further scan showed increased. So again biopsy done and it showed tnbc and also ngs panel done and it says pic3 mutation and now completed 6 cycles of carbo and docetaxol chemo and waiting fof pet scan now but doctor sayinf next treatment will be Alpelisib and Fulvesterant injection. But this alpelisib is too costly here in india and also not sure whether insurance is gonna cover it. Any advise? Attached ngs report
Good evening Doctor.
I had intramucosal adenocarcinoma of the rectum about 9 years ago, arising from a tubulovillous adenoma (2 × 2 cm), moderately differentiated, with no invasion beyond the muscularis mucosa. Only polypectomy was done, and no further treatment was required. The report showed MSI negative / MMR proficient.
At that time MRI pelvis and CT scan were normal, and post-polypectomy site biopsy showed no dysplasia or malignancy.
Follow-up done regularly: • Colonoscopy – about 10 times, all normal (last on 12 November 2025)
• USG whole abdomen – 10 times, all normal
• Blood tests – about 6 times, normal
• Chest X-ray (PA) – 4 times, normal
Kindly advise the appropriate interval for future surveillance colonoscopy. Also, if a new polyp appears in future, would it necessarily be malignant in my case, or usually benign?
. Kindly send your advice by SMS when convenient. Thank you.
I have white discharge from my right breast nipple, when I squeezed it, a small white drop came out. I have a slight pain in my nipple. Then my periods are delayed. Then I have hypothyroidism. What could be the reason? Is there a chance of cancer?
