Hello Doctor,
Seeking your opinion regarding a 71-year-old patient diagnosed with NSCLC favor squamous cell carcinoma (P40 diffuse positive, TTF1 negative) involving the right upper lobe. PET-CT shows a spiculated RUL lesion approx. 3.0 × 4.7 × 4.0 cm with SUV max 16.58. Mildly FDG-avid hilar/paratracheal nodes (SUV ~4.2) with some calcification noted. EBUS/TBNA from stations 4R, 7 and 11L showed no evidence of malignancy. Current staging documented as cT2bN1M0 (Stage IIB). Proposed plan is neoadjuvant chemotherapy followed by reassessment for surgery.
Would appreciate guidance on:
1. Whether chemo + surgery appears the optimal curative-intent approach in this case.
2. Whether adding immunotherapy to neoadjuvant chemotherapy would significantly improve outcomes.
3. Whether current imaging/EBUS findings sufficiently support N1 staging or need further nodal evaluation.
Thank you.
Hi, as part of my pre-IVF evaluation I underwent a hysteroscopy procedure in 2024. The biopsy results came back negative for CD138 but showed signs of endometrial hyperplasia. After this I was induced for egg retrieval twice back to back and then I took a break for a year. All this while I was never given any treatment for hyperplasia. Now this year that is 2026, I started my IVF journey again and my uterus had polyps. Since I am not a doctor, I do not understand why I was not given any treatment for hyperplasia. I only understood this when I did some study on my old report findings. I am now scared that what if it turned into cancer. My whole life would go for a toss for an ignorant doctor. What are you experience in such cases. What is the most worst that can happen to me. I will be doing a biopsy again but I want to know the reality what to expect.
I was undergoing IVF treatment which started in 2024 as part of my pre-IVF assessment. I was given a diagnostics hysteroscopy that revealed that I had hyperplasia without atypia in 2024. I don't remember that my doctor was concerned during that time and the only treatment that I was given was Crina 10 for 10 days for my spotting in leutal phase. Now I this year. I am due for an embryo transfer and again, my doctor was examining my uterus and she mentioned that I have polyps in my uterus and when I referred to my past report just to see that what it said in 2024 i found about the hyperplasia and when I did some googling, I understood that this is a serious condition that should have been taken care. I am due for another hysteroscopy but I am scared as this was ignored. Reports from 2024 biopsy attached
Detected BONE MARROW (Multiple Mylomia), in 2016.(Near spinal cord)
Blood Test indicated 25% Plasma Cell, in 2016.
So far done this Tests 16 times, till last month.
Now it is 1 %.
Should I take that now I have been cured almost of Multiple Myloma.
No medicine since last 6 months.
( Before that took THALIX-100 : 1 Tablet /day.)
Thanks
What should be the next treatment? How can we treat this Conventional prostatic adenocarcinoma with neuroendocrine differentiation and an extensive small cell type? He has aged alot , psa is 1.1, Intense FDG uptake noted in peripheral zone of right lobe of enlarged prostate (measures 5.0x4.3 cm);
SUVmax 10.9
FDG avid bilateral external iliac, left obturator nodes; ~ 3.1x2.5 cm, SUVmax 9.5
FDG avid few bilateral hilar, subcarinal, paratracheal, prevascular nodes (largest measures 1.8x0.9 cm;
SUVmax 8.5), few of them demonstrating hyperattenuation of NCCT thorax: favours the granulomatous etiology.
No other significant adenopathy noted
FDG avid extensive lytic and marrow lesions (few with associated soft tissue; Intraspinal extension at the level of few dorsal-lumbar vertebrae and sacrum) are noted involving axial and proximal appendicular skeleton; SUVmax 9.5.
Variable FDG avid varying sized hypodense lesions in both lobes of liver; largest measures ~ 2.5x3.0 cm (segment V), SUVmax 14.5
