Hello Doctor, my mother has ovarian cancer and has completed 4 cycles of neoadjuvant chemotherapy with very good response (CA-125 reduced from 273 to 11). Her treating team is now planning interval cytoreductive surgery with HIPEC.
We would like to take an expert opinion specifically regarding whether HIPEC is truly necessary/beneficial in her case, considering the additional recovery burden and cost. Could you please help us in deciding if HIPEC would be necessary and effective ?
Thank you.
Hello Doctor,
Seeking your opinion regarding a 71-year-old patient diagnosed with NSCLC favor squamous cell carcinoma (P40 diffuse positive, TTF1 negative) involving the right upper lobe. PET-CT shows a spiculated RUL lesion approx. 3.0 × 4.7 × 4.0 cm with SUV max 16.58. Mildly FDG-avid hilar/paratracheal nodes (SUV ~4.2) with some calcification noted. EBUS/TBNA from stations 4R, 7 and 11L showed no evidence of malignancy. Current staging documented as cT2bN1M0 (Stage IIB). Proposed plan is neoadjuvant chemotherapy followed by reassessment for surgery.
Would appreciate guidance on:
1. Whether chemo + surgery appears the optimal curative-intent approach in this case.
2. Whether adding immunotherapy to neoadjuvant chemotherapy would significantly improve outcomes.
3. Whether current imaging/EBUS findings sufficiently support N1 staging or need further nodal evaluation.
Thank you.
I see now a days that many people after 60 years are diagnosed with cancer . The thing is, it is diagnosed in the last stage. Is there a test that we can perform every 6 months that can point out early stage cancer any where in the body?.
My father is suffering from CLM (Chronic Myeloid Leukemia), Local Oncologist advised to take "BOSUTINIB 500 mg" but the Medicine doesn't suits on him, so many health issues arises after taking the Medicine. Earlier he was taking Tab "Imatinib 400" since 2018. Now patellate count has increased,& Hb is very low, Please Guide what to do now
What should be the next treatment? How can we treat this Conventional prostatic adenocarcinoma with neuroendocrine differentiation and an extensive small cell type? He has aged alot , psa is 1.1, Intense FDG uptake noted in peripheral zone of right lobe of enlarged prostate (measures 5.0x4.3 cm);
SUVmax 10.9
FDG avid bilateral external iliac, left obturator nodes; ~ 3.1x2.5 cm, SUVmax 9.5
FDG avid few bilateral hilar, subcarinal, paratracheal, prevascular nodes (largest measures 1.8x0.9 cm;
SUVmax 8.5), few of them demonstrating hyperattenuation of NCCT thorax: favours the granulomatous etiology.
No other significant adenopathy noted
FDG avid extensive lytic and marrow lesions (few with associated soft tissue; Intraspinal extension at the level of few dorsal-lumbar vertebrae and sacrum) are noted involving axial and proximal appendicular skeleton; SUVmax 9.5.
Variable FDG avid varying sized hypodense lesions in both lobes of liver; largest measures ~ 2.5x3.0 cm (segment V), SUVmax 14.5
