What should be the next treatment? How can we treat this Conventional prostatic adenocarcinoma with neuroendocrine differentiation and an extensive small cell type? He has aged alot , psa is 1.1, Intense FDG uptake noted in peripheral zone of right lobe of enlarged prostate (measures 5.0x4.3 cm);
SUVmax 10.9
FDG avid bilateral external iliac, left obturator nodes; ~ 3.1x2.5 cm, SUVmax 9.5
FDG avid few bilateral hilar, subcarinal, paratracheal, prevascular nodes (largest measures 1.8x0.9 cm;
SUVmax 8.5), few of them demonstrating hyperattenuation of NCCT thorax: favours the granulomatous etiology.
No other significant adenopathy noted
FDG avid extensive lytic and marrow lesions (few with associated soft tissue; Intraspinal extension at the level of few dorsal-lumbar vertebrae and sacrum) are noted involving axial and proximal appendicular skeleton; SUVmax 9.5.
Variable FDG avid varying sized hypodense lesions in both lobes of liver; largest measures ~ 2.5x3.0 cm (segment V), SUVmax 14.5
I have been a CML patient since 2016 and have had undetectable reports since 2023. Since last year due to family and personal issues. I became alcohol sober and can't skip any day. I was told by a doctor friend that Neltrexone 50mg will help me to stop alcohol. But I am afraid whether it will interact with my CML medicine. Please advise I am living a very bad life.
Please help me answer.
Good evening Doctor.
I had intramucosal adenocarcinoma of the rectum about 9 years ago, arising from a tubulovillous adenoma (2 × 2 cm), moderately differentiated, with no invasion beyond the muscularis mucosa. Only polypectomy was done, and no further treatment was required. The report showed MSI negative / MMR proficient.
At that time MRI pelvis and CT scan were normal, and post-polypectomy site biopsy showed no dysplasia or malignancy.
Follow-up done regularly: • Colonoscopy – about 10 times, all normal (last on 12 November 2025)
• USG whole abdomen – 10 times, all normal
• Blood tests – about 6 times, normal
• Chest X-ray (PA) – 4 times, normal
Kindly advise the appropriate interval for future surveillance colonoscopy. Also, if a new polyp appears in future, would it necessarily be malignant in my case, or usually benign?
. Kindly send your advice by SMS when convenient. Thank you.
Need consultation with best uro Oncologist in New Delhi. BCG 80 mg applied 6 times at an interval of one week, after cystoscopy no appearance of tumor cells, but then after maintenance dose 3 times at an interval of one week, lesions appear, may be tumor.
I have white discharge from my right breast nipple, when I squeezed it, a small white drop came out. I have a slight pain in my nipple. Then my periods are delayed. Then I have hypothyroidism. What could be the reason? Is there a chance of cancer?
