Li-Fraumeni Syndrome Treatment

Health Q&A
Family History of Cancer

Hi Doctors, My father is currently suffering from oral cancer, and several other members of his side of family, including my paternal aunt (bua), have also passed away due to cancer. I wanted to understand whether cancer can be hereditary and whether this family history increases my chances of developing cancer in the future. Would you recommend genetic counselling or any screening or preventive measures for me?

Heart stroke due to JAK2 MUTATION +ve

My father got heart stroke in 2019 and got performed BONE MARROW and find out JAK2 mutation positive(2019). Now( Sep 2026) he lost weight(from 4 months), feeling weakness and his haemoglobin is 9% due to anemia. His heart ejection factor is 25%. haemotogist suggested for BONE MARROW. Is bone marrow mandatory? Considering his age and heart issue Do we have other tests to identify the root cause.

Mammography reports

Mammography report .pls check and advise............ .........................................,,,,,

Will she get cancer or not?

My partner is a 31 year old woman. (We are a same sex couple). Cancer runs in her family. Her mother died of breast cancer when she was only 34 years old. Her mother's sister also had breast cancer after that and might probably have it again. Her mother's sister is currently 55 years old. So, what are the chances that my partner might get cancer in the future too? She will be going for a BRCA1 and BRCA2 gene test. What if she has inherited the cancer gene? If so, will it be breast cancer or any kind of cancer? She also smokes occasionally but wants to quit it. What can she do to prevent it?

Any cure for this cancer?

Hello Doctor. My father has tongue squamous cell carcinoma. He received 3 cycles of chemotherapy (Nov-Jan), and the tumor shrank significantly. He then completed 36 radiation sessions, after which it reduced even further. However, after 3 months of oral chemotherapy tablets, the cancer has progressed. Our local oncologist says there is almost no chance of survival, but I don't want to lose my father without exploring every possible option. Is there any treatment—different chemotherapy, immunotherapy, targeted therapy, surgery, re-irradiation, embolization, or a clinical trial—that could shrink the tumor, improve his airway and swallowing, or even offer a chance of long-term control or cure? Since he responded well to the initial chemotherapy, could another regimen help again? We are willing to travel anywhere in India for the best possible treatment. Thank you.

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Doctors
Dr. William E. Carson - Oncologist
Dr. William E. Carson Oncologist (Medical School, Residency, BS in Biological Sciences, Residency in Surgery (Gen), Fellowship, Complex General Surgical Oncology, Fellowship in Oncology Surgical, Internship, Surgery (General Surgery), Residency in Surgery (General)) 40 years experience The Ohio State University Wexner Medical Center
Weinland Park, COLUMBUS
Dr. William E. Carson - Oncologist
Dr. William E. Carson Oncologist (Medical School, Residency, Fellowship in Oncology Surgical, Internship, Surgery (General Surgery), Residency in Surgery (General), BS in Biological Sciences, Class of 1986, Residency in Surgery (Gen), Fellowship, Complex General Surgical Oncology) 40 years experience The Ohio State University Wexner Medical Center
Weinland Park, COLUMBUS
Dr. Eric H. Kraut - Internal Medicine
Dr. Eric H. Kraut Internal Medicine (Medical School, Residency, Clinical Fellowship in Hematology and Medical Oncology, Residency in Internal Medicine, Class of 1972) 54 years experience The James Cancer Hospital And Solove Research Institute
Columbus 43210, COLUMBUS
Dr. Nseobong I Ntukidem - Internal Medicine
Dr. Nseobong I Ntukidem Internal Medicine (Medical School, Residency, Internship, Residency - ID, Fellowship 2, Residency in Internal Medicine, Fellowship in Pharmacology, Fellowship in Medical Oncology, Medical Education) 34 years experience Columbus Oncology Associates
Columbus 43214, COLUMBUS
Dr. Luis  Vaccarello - Oncologist
Dr. Luis Vaccarello Oncologist (Medical School, Residency, Medical Education, Medical degree, DO, Residency in Obstetrics and Gynecology, Fellowship in gynecologic oncology) 42 years experience Mid-Ohio Oncology Hematology
Columbus 43219, COLUMBUS