My dad had bowel on and off for 6 months. A gastro specialist did colonoscopy and report said a mass in rectosigmoid region 10cm from anal bulge neoplastic? pet ct said luminal narrowing of the colon wall causing dilation of large bowel immedietly we got the surgery done immedietly and tumour removed tumour biopsy said all 12 lymph nodes are free t3N0 lvi plus pni plus emvi plus and high budding. Heart ef 40 to 45 percent. My question is that shall we go for ctdna or not and also as per mosiac trial they say that chemo specially oxilaplatin benefit in high risk stage 2 disease is very limited compared to stage 3 disease so shall we skip oxilaplatin and prefer only s1 or skip chemo totally if ctdna negative
Please advise whether to do ct dna or go for chemo directly or omit chemo totally outwieghing the risk of toxicity
My dad was having stool on and off since last 6 months after doing colonoscopy we noticed a mass in rectosigmoid region 10cm from anal bulge pet ct said luminal narrwing in rectosigmoid region causing dilation of proximal larhe bowel he underwent colostomy surgery and is now recovering. doctors prescribed chemo qfter it was mss and eF of heart 45 percent with oxilaplatin and s1. my question is that isnt oxilaplatin too toxic for high risk stage 2 because in mosiac trail they say that oxilaplatin almost adds neglible benefits in overall life for high risk stage 2 patients compared to stage 3 patients...also he is very fine walking eating smiling and energetic well i m very confused that after chemo it might not be the same...pls help also is ctdna test or any other tests required to check further or chemo is important. we are giving him superb high antioxidant diet in his recovery days after surgery
Hello Doctor,
Seeking your opinion regarding a 71-year-old patient diagnosed with NSCLC favor squamous cell carcinoma (P40 diffuse positive, TTF1 negative) involving the right upper lobe. PET-CT shows a spiculated RUL lesion approx. 3.0 × 4.7 × 4.0 cm with SUV max 16.58. Mildly FDG-avid hilar/paratracheal nodes (SUV ~4.2) with some calcification noted. EBUS/TBNA from stations 4R, 7 and 11L showed no evidence of malignancy. Current staging documented as cT2bN1M0 (Stage IIB). Proposed plan is neoadjuvant chemotherapy followed by reassessment for surgery.
Would appreciate guidance on:
1. Whether chemo + surgery appears the optimal curative-intent approach in this case.
2. Whether adding immunotherapy to neoadjuvant chemotherapy would significantly improve outcomes.
3. Whether current imaging/EBUS findings sufficiently support N1 staging or need further nodal evaluation.
Thank you.
Hi, as part of my pre-IVF evaluation I underwent a hysteroscopy procedure in 2024. The biopsy results came back negative for CD138 but showed signs of endometrial hyperplasia. After this I was induced for egg retrieval twice back to back and then I took a break for a year. All this while I was never given any treatment for hyperplasia. Now this year that is 2026, I started my IVF journey again and my uterus had polyps. Since I am not a doctor, I do not understand why I was not given any treatment for hyperplasia. I only understood this when I did some study on my old report findings. I am now scared that what if it turned into cancer. My whole life would go for a toss for an ignorant doctor. What are you experience in such cases. What is the most worst that can happen to me. I will be doing a biopsy again but I want to know the reality what to expect.
Can OSMF still progress even after quitting the habit, and will there still be any kind of cancer risk?
