Hi,
My mother got diagnosed with upfront mbc on nov 2023 and that time it was er pr +ve and her2 negative so taxol given for 6 cycle then palbociclib with letro went for nearly 1.7 yrs then progression and did re biopsy then its changed to triple negative and also did gene and ngs test. Gene test came negative but ngs test showed pik3ca mutation and pd L1 also came negative. Then docetaxol and carboplaton chemo went for 6 cycle then few days back pet scan done but no response and its progressed again on liver. Now doctor suggested alpelisib and fulvestrant and started on it. Am really worried will alpelisib works on this tnbc? And how long can be managed and also aide effects etc.
Recently did a PET SCAN for my father, where the Renal mass is less than 4 cm, FDG intake is low and for the lung nodules comments are looks like inflamatory than metastasis, we are planinng for Nephrectomy, but am worried with the lung nodules , can anyone please suggest
My mother was diagnosed upfront as metastatic breast cancer on Nov 2023. At that time it was ER PR positive Her2 negative so first treatment was taxol chemo 6 cycle and then tumor reduction and given palbociclib tablet with letrozole for an year and half hr then further scan showed increased. So again biopsy done and it showed tnbc and also ngs panel done and it says pic3 mutation and now completed 6 cycles of carbo and docetaxol chemo and waiting fof pet scan now but doctor sayinf next treatment will be Alpelisib and Fulvesterant injection. But this alpelisib is too costly here in india and also not sure whether insurance is gonna cover it. Any advise? Attached ngs report
Good evening Doctor.
I had intramucosal adenocarcinoma of the rectum about 9 years ago, arising from a tubulovillous adenoma (2 × 2 cm), moderately differentiated, with no invasion beyond the muscularis mucosa. Only polypectomy was done, and no further treatment was required. The report showed MSI negative / MMR proficient.
At that time MRI pelvis and CT scan were normal, and post-polypectomy site biopsy showed no dysplasia or malignancy.
Follow-up done regularly: • Colonoscopy – about 10 times, all normal (last on 12 November 2025)
• USG whole abdomen – 10 times, all normal
• Blood tests – about 6 times, normal
• Chest X-ray (PA) – 4 times, normal
Kindly advise the appropriate interval for future surveillance colonoscopy. Also, if a new polyp appears in future, would it necessarily be malignant in my case, or usually benign?
. Kindly send your advice by SMS when convenient. Thank you.
Hello my father has been diagnosed by HCC liver cancer BCLC stage Child pugh-A
Can u please suggest me treatment
Which is the best option immunotherapy Injections or TACE
