Seeking expert opinion for a 62F with signet ring cell carcinoma of sigmoid colon diagnosed July 2025. She underwent surgery (LAR + hysterectomy + BSO) followed by chemotherapy (Dacotin + Capecitabine). Latest PET-CT Feb 2026 shows no liver, lung, brain metastasis and no residual primary lesion. However, there are FDG-avid peritoneal nodules (SUV ~7) with mild ascites, suggestive of post-op changes vs residual disease. Kindly advise on further management, chemotherapy strategy, CRS alone or CRS with HIPEC suitability or second line chemo.
I have checked everything except for colonoscopy, all are normal according to doctors, apart from grade 1 fatty liver, it is over 3 months I don't somke and drink, all CA markers are normal, still my fear of cancer keeps coming back, please suggest what to do
Hi,
My mother got diagnosed with upfront mbc on nov 2023 and that time it was er pr +ve and her2 negative so taxol given for 6 cycle then palbociclib with letro went for nearly 1.7 yrs then progression and did re biopsy then its changed to triple negative and also did gene and ngs test. Gene test came negative but ngs test showed pik3ca mutation and pd L1 also came negative. Then docetaxol and carboplaton chemo went for 6 cycle then few days back pet scan done but no response and its progressed again on liver. Now doctor suggested alpelisib and fulvestrant and started on it. Am really worried will alpelisib works on this tnbc? And how long can be managed and also aide effects etc.
I have the cyst on the back of the neck in nape area where hair line ends atleast from 3 years . And suddenly from past 1year it grows a little it doesn't give any discomfort to me and it feels like movable it feels like 2 cm soft marble . Should I worry or not ?
I have been a CML patient since 2016 and have had undetectable reports since 2023. Since last year due to family and personal issues. I became alcohol sober and can't skip any day. I was told by a doctor friend that Neltrexone 50mg will help me to stop alcohol. But I am afraid whether it will interact with my CML medicine. Please advise I am living a very bad life.
Please help me answer.
