Severe weakness with calf muscle pain warrants clinical evaluation rather than assuming a
vitamin deficiency.
Suggested investigations, guided by history and examination:
- Serum 25-OH
vitamin D
- Serum
vitamin B12; consider folate if indicated
- CBC review and
ferritin/iron studies if iron deficiency is suspected
- Renal function,
calcium, phosphate and magnesium
- CK (creatine kinase) if significant muscle pain, tenderness or objective weakness is present
- ESR/
CRP if inflammatory symptoms are suspected
Review dietary intake, menstrual blood loss, recent infections, physical activity, medications and neurological symptoms. Supplement vitamin D or B12 if deficiency is confirmed or strongly suspected; avoid high-dose vitamin D without appropriate assessment.
Important: If one calf is swollen, red, warm or distinctly more painful than the other, urgently evaluate for deep-vein thrombosis. Breathlessness or chest pain requires emergency assessment. Progressive weakness, difficulty walking, saddle numbness, or new bladder/bowel dysfunction also requires urgent evaluation.