Hello, I am Dr. Romain Rajan, General Physician. I understand your concern â It is frustrating to be on
thyroid medication yet still feel unwell with persistent fatigue and body pain. Your current lab results, showing a slightly high
TSH (5.030 μIU/mL), a normal Free T4, and a low T3 (64.4 ng/dL), suggest that your body may not be converting the T4 from your medication (Thyronorm) into the active T3 hormone effectively.
Advices
Maintain a consistent schedule for taking your 25 μg Thyronormâalways take it first thing in the morning on an empty stomach with water, and wait at least 30-60 minutes before having breakfast, coffee, or any other medication.
Ensure adequate intake of key nutrients like Selenium and Zinc, which are crucial co-factors for the enzyme that converts T4 to T3. You can find these in nuts (like Brazil nuts), seeds, and seafood.
To potentially help with muscle and joint pain, try gentle, low-impact exercises like walking or stretching, which can improve blood flow and reduce stiffness.
Why Your T3 Might Be Low
A low T3 level while on Levothyroxine (Thyronorm) suggests a conversion problem, meaning your body isn't efficiently turning the storage hormone (T4) into the active hormone (T3).
Possible reasons for this conversion issue include:
Nutrient Deficiencies: Deficiencies in essential co-factors like Iron, Zinc, or Selenium are very common causes of poor T4-to-T3 conversion.
Chronic Stress or Inflammation: Elevated stress hormones (like cortisol) can inhibit the conversion process, which is often seen alongside chronic pain and fatigue.
Recent Illness/Viral Infection: Your body's response to any recent illness can temporarily suppress T3 production (a phenomenon called euthyroid sick syndrome, or low T3 syndrome), which often takes time to recover.
Medication/Supplement Interactions: While Omega-3 Fish Oil typically doesn't directly lower T3, it's possible it temporarily affected absorption or conversion mechanisms in your system. Crucially, supplements like
Calcium, Iron, and certain antacids must be taken at least 4 hours apart from Thyronorm as they interfere with its absorption.
What to Monitor
Note the exact time you take your Thyronorm and how long you wait before eating or taking other supplements.
Be watchful for mild warning signs, including increasing swelling, worsening fatigue that affects your daily functioning, or new symptoms like depression or noticeable hair loss.
Managment
You may try a safe, over-the-counter supplement like Magnesium Glycinate to help ease your muscle and spine pain, and potentially improve sleep quality. Please avoid making any changes to your Thyronorm dosage or adding complex supplements without consulting a doctor, as your treatment needs to be adjusted based on the specific reason for the low T3.
When to Consult a Doctor Immediately
Pitting edema (severe swelling) in your legs or ankles that leaves an indentation when you press it.
Sudden onset of chest pain or palpitations.
Worsening depression or extreme sluggishness that makes it difficult to function.
Every patientâs situation is unique. Your symptoms of fatigue, muscle pain, and headache, combined with the low T3, indicate that a simple dosage change may not be enough; we need to investigate the reason for the poor T4-to-T3 conversion.
ð You can reach out to me directly for this case, and also connect with me in the future for any medical consultation.
I am available on Practo or on WhatsApp at 85271646 seven seven for a one-on-one consultation, where youâll receive:
A personalized treatment plan that may include necessary nutritional supplements to boost T4-to-T3 conversion.
Safe medicine adjustments (which may involve slightly increasing your Thyronorm) (if required).
Quick follow-ups to track your recovery and symptom improvement.
Take care, wishing you good health.
Best regards,
Dr. Romain Rajan
General Physician