INTODUCTION
Mesotherapy is a non surgical skin rejuvenation treatment. Mesotherapy is that the procedure that involves multiple intradermic or body covering injections of a mix of compounds which has bioactive substances, mucopolysac- charide, prescribed drugs, plant extracts, medical aid agents, vitamins in minute doses, using terribly fine gauge needles to treat native medical and cosmetic conditions.1The mechanism of action of mesotherapy is that solutions are injected into germ layer stay within the space longer than they’d if distributed by deeper injection; as they’re clearly added bit by the final circulation. The depth of needle penetration must not over four metric linear unit.Mesotherapy treatment is employed for many native medical and cosmetic conditions like loss of skin tone, loss of glow, skin aging, superficial wrinkles, hair loss. Study conjointly includes the lipolytic potential of resolution utilized in the apply of cosmetic mesotherapy to stimulate lipolysis inflicting native fat reduction.
MECHANISM OF ACTION
The skin acts as a natural time-release system once medication is injected by mesotherapy. The mechanism of action of mesotherapy is that the solutions that is injected intracutaneously stay within the space for very long time than they’d if distributed via deeper injection. These preparations contain vitamins, trace components, enzymes, opposing oxidiser, organic compound and alternative active substances poignant the standard of skin. Absorbed by skin, these substances stimulate the albuminoid and elsatin production, reconstructing the inner structure of skin, smoothing wrinkles, restoring the skin tone and snap, returning the healthy glowing look. The primary impact of mesotherapy is rejuvenated, lowerclassman face and also the second – mesolifting, increase skin firmness and even reasonably stretch.
Mesolift/Mesoglow/Biorejuvenation
Commonly the terms used for the treatment of skin of face and neck rejuvenation area unit Mesoglow or Mesolift. Agents unremarkably used for mesolift –
Hyaluronic acids-
one amongst the glycosaminogly can used within the method to boost the tone and physical property of the skin by binding and retentive the water content.
Multivitamins, trace elements -
Multi vitamins are used for ionic balance of the skin.
Amino acids, vegetal proteins-
Amino acids and vegetal proteins are used for reconstruc- tion.
Alopecia
Mesotherapy is advanced resolution for hair loss and phalacrosis. Dudasteride is employed during this treatment. Du-tasteride is the solely Sa-convertase matter that is restricted to each receptor one and receptor two. It’s been clinically tested to produce hair by injecting dutasteride directly into the scalp at a depth of one to three millimetre. Initial treatment is given anyplace from once per week to once each five weeks. Alternative substances that area unit additionally utilized in the treatment of phalacrosis embody vitamin H, finasteride, etc.
Localised fat deposits/injection lipolysis (double chin, eye pad fats)
Deoxycholate and Phosphatidyl vitamin B (PC) and are the foremost unremarkably used agents for dissolving of fat. Phosphatidyi is an inhibitor and it’s derived from soybean phospholipid. Depth of injection for injection lypolysis and localised fat deposit varies from half dozen millimetre to twelve millimetre at a dose of 250 mg. Phosphatidyl, when penetrating the adipocytes cells, it breaks down the fat cells that through the blood stream are excreted by the urinary organ system. It (b) Promotes lipolysis by stimulating receptors and inhibiting a pair of receptors on the adipocyte membrane. (c) And additionally causes inflammatory cytokine-mediated gangrene and organic process of adipocytes. New scleroprotein is created once the inflammation subsides that causes retraction of the unsnarled tissues.
SideEffects
Side effects and adverse outcomes following mesotherapy are rare in experienced hands. Appropriate training and ongoing education are vital to retain competence and skill. Common side effects are pain, erythema, oedema, bruising, bleeding and scratch marks. These side effects can be attributed to the nature of the procedure and the techniques adopted. Itching or allergic reactions could also be related to the active substances used during treatment. It is congruent with safe practice that aesthetic practitioners are familiar with the active ingredients in their chosen mesotherapy preparations. Some patients also report feeling ‘wind burnt’ and a ‘tightness’ in their skin in the first 24 hours post procedure. This is the needle response stimulating an inflammatory process and will abate with 24 hours. Poor attention to aseptic technique can lead to localised infections and erythematous nodules. Several cases of cutaneous Mycobacterium abscessus infection have been reported following mesotherapy and soft tissue augmentation procedures provided by unlicensed practitioners.
Conclusion
Mesotherapy is a new, effective and safer technique for treatment of conditions like alopecia, skin rejuveantion, hyperpigmentation. Mesotherapy require less time for treatment hence it is preferred over treatments. The future of mesotherapy whether it can become part of Maxillofacial surgey. Plastic Surgery, Dermatology.