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Advanced stage lung adenocarcinoma
My mother is suffering from advanced(stage IV) Lung adenocarcinoma, she was diagnosed in December 2024 with metasis to liver and bones and she was further put on targeted therapy as it was EGFR and TP53 mutated- Osimertinib and Chemotherapy and it worked and resulted clear PET CT scans until recently . After a year of diagnosis, recently in May 2026 she went through PET CT scans following a swallowing difficulty and it was found that the cancer had become active again(not at the primary site) at the either side of the hilar nodes and in the esophagus (outer part not inside) now doctor has recommended Amivantamab and carboplatin chemotherapy. I want to know if this will work as she is havina a lot of complication while swallowing food and is having purely liquid diet. For how much time will it be effective? Doctor has said 1yr so really one yr or it depends? Is the line of treatment that is being followed ,correct ?
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Yes the line of treatment is absolutely correct
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The advised treatment is as per the recommendation and correct. About further prognosis- as per the trial the median time after which the disease will progress (mPFS) will be around 6 month or so. After next progression- again an NGS would be done. And if no further mutations found- probably it will be good to go for an immunotherapy combination now like- ABCP regimen. Regards.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.