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CML (bcr abl)
My father got diagnosed with cml in June 2024 and started with dasatinib but due to continuous low blood counts switched to imatinib. Now after being 5 months on imatinib bcr abl increases from 0.3% to 1.3%. Doctor said change in value is due to different lab used and not to worry. He advised next bcr abl after 3 months. I am worried what if bcr abl keeps on increasing and disease progress. All the other blood counts are in normal range. Please help
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Can help you with the next course of action and treatment plan. Kindly consult via whatsapp at nine zero two nine six zero zero four seven zero.
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You will need to consult an oncologist
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Don't worry as you are on medication.
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Continue consulting with hemato-oncologist.
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Need evaluation
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Need to look at pt overall improvement before coming into conclusion about how to proceed
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Consult a specialist
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Hello
Thank you for sharing your concerns about your father’s CML (BCR-ABL) status. While the increase from 0.3% to 1.3% could be due to lab variability as suggested by the doctor, it is important to monitor this trend closely. CML management relies heavily on achieving and maintaining molecular response, and any upward trend in BCR-ABL levels should be evaluated carefully to rule out resistance or suboptimal treatment response.
Since your father has already switched therapies due to tolerability issues, a detailed review of his case—including possible mutation testing or dose adjustments—may be necessary. I strongly recommend a **consultation with a CML specialist** to ensure the best course of action.
For further discussion or to schedule an appointment, you can reach me on WhatsApp at **Eight Zero Zero Nine Eight Two One Three Three Two**. Early intervention can make a significant difference in long-term outcomes.
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Oncologist consultation.
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Consult from hemato oncologist. Follow whatever been adviced.
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Repeat bcr abl.
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Consult oncologist
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Hi,
When we look at CML and response to treatment we assess a few things
1. Molecular response : BCR ABL levels
2. Hematological response : based on CBC and peripheral smear
3. Cytological response: based on a bone marrow aspirate
At around 6 months of treatment we aim for a BCR ABL of less than 1% as optimal. So if you are worried about the rising signals, you should ask the doctor to suggest the standard lab he/she prefers. Get it repeated.
(Generally for certain tests, you need good labs and the nearest lab might not be the best source)
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Consult if required
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Do connect and consult
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Dr. Manoj Kumar
General Physician
9 yrs exp
Dehradun
Need few more details
Kindly consult
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Dr. Ashita Kuruvilla
General Practitioner
8 yrs exp
Kolkata
Need few more details for proper evaluation. Kindly consult
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Dr. Anubha Singh
General Physician
4 yrs exp
Jhansi
If you require assistance or have any health concerns, feel free to reach out for a consultation. Your well-being is my priority, and i'm here to support you on your health journey.
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Dr. Thresia Pereira
General Physician
37 yrs exp
Mumbai
Please continue to consult with Haematologist
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Dr. Saurabh Tiwari
Neuropsychiatrist
6 yrs exp
Lucknow
Kindly connect
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Dr. Himani Shah
General Physician
9 yrs exp
Rajkot
Need to connect immediately
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Dr. Vikram Pratap
General Physician
12 yrs exp
New Delhi
You should visit an Oncologist
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Dr. Koushik
MBBS
4 yrs exp
Karimnagar
Kindly consult
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Dr. Konica gupta
General Physician
4 yrs exp
Ghaziabad
Oncologist opinion
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Dr. Neha Raut
General Physician
9 yrs exp
Pune
Take oncologist opinion
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Dr. Ram Brahma Reddy
General Physician
6 yrs exp
Hyderabad
Kindly consult
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Dr. Asha Garg
General Physician
27 yrs exp
Muktsar
Your consultant is right. Please follow his advice
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Dr. Javed Akhtar
General Medicine
4 yrs exp
Guwahati
Oncology consultation
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Dr. Anuj Mothsra
General Physician
6 yrs exp
Jhunjhunu
Take oncologist opinion
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Dr. Shaikh Huzaif
General Physician
18 yrs exp
Aurangabad
Please consult
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.