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Multiple myeloma
On a routine test in June, my 59 y/o mother had slightly high serum globulins (4.7) and slightly high calcium (10.3) So we did the following tests :- 1- Serum protein electrophoresis - Came back normal with no M spike 2- Serum FLC - Kappa - 33.1 (Ref- 3.3 to 19.4) -  Slightly high Lambda - 18.1 - Normal Kappa/Lambda ratio - 1.83 (Ref- 0.26 to 1.65) Her calcium is back to normal now (without medications). At present, her calcium is 8.9, Hb is 12.5, serum globulin is 3, creatinine is 0.75, urea is 25 and x rays have shown arthiristis. So she doesn't have anemia, hypercalcemia, kidney damage or bone lesions, as of now. However, her kappa chains are elevated and kappa/lambda ratio is slightly high. What is it pointing towards ? Could it be multiple myeloma ?
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First of all you have compiled reports and history very well. This does not look multiple myeloma. Elevation of single kappa or lambda does not point out myeloma.
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you can repeat the same tests after 6 months
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No it cannot be multiple myeloma. You can have a discussion with your hematologist regarding elevated light chain essays. From the looks of it it seems to be MGUS which has very low rate of progression to myeloma m
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.