Sir My mother had severe diarrhea on 26 nov .got her admitted .They put her on inj monocef inj metrogyl as crp and tlc was high.ultrasound was ok.she got discharged after 3 days.
After 12 days she again had severe diarrhea no fever again got admitted this time again cro and tlc were high.tlc 15700.
Ccet was done showed mild inflammation in intestines
She was on meropenem and metrogyl and rifagut this time.her tlc on day 1 was 8500
Day2 9500
Day5 9900
Now after one week 10100 and crp 4.5
We know tlc is in limit but why it is increasing again day by day..
What if tlc shoots up again..please guide
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Recurring diarrhea with increasing total WBC count and CRP indicates intestinal infection.Antibiotc induced diarrhea caused by c difficle should be considered and other causes as well.She may need specific stool tests and blood tests.
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Dear Patient,
Your mother's recurrent severe diarrhea, accompanied by elevated total leukocyte count (TLC) and C-reactive protein (CRP), suggests an ongoing inflammatory or infectious process. The initial improvement followed by a gradual increase in TLC, despite being within normal limits, warrants further investigation to identify the underlying cause.
Potential Considerations:
Infectious Etiology: Persistent or recurrent infections, including Clostridioides difficile (C. difficile), can cause similar symptoms. A stool test for C. difficile toxin is advisable, especially considering recent antibiotic use.
Inflammatory Bowel Disease (IBD): Conditions like ulcerative colitis or Crohn's disease could present with these symptoms. Elevated inflammatory markers such as CRP and TLC are common in IBD. Fecal calprotectin testing can help assess intestinal inflammation and guide the need for further endoscopic evaluation.
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Medication-Induced Diarrhea: Some medications, including certain antibiotics, can cause diarrhea. Reviewing her medication history may help identify potential culprits.
Recommended Next Steps:
Comprehensive Stool Analysis: Testing for pathogens, including C. difficile, and assessing fecal calprotectin levels can provide insights into infectious or inflammatory causes.
Colonoscopy with Biopsy: If stool studies are inconclusive, a colonoscopy can help visualize the colon and obtain tissue samples to diagnose conditions like microscopic colitis or IBD.
Medication Review: Evaluate her current medications with her healthcare provider to identify any that might contribute to diarrhea.
Consult a Gastroenterologist: A specialist can provide a thorough evaluation and recommend appropriate diagnostic and therapeutic interventions.
It's important to monitor her symptoms closely. If she experiences increased diarrhea, abdominal pain, fever, or other concerning symptoms, seek medical attention promptly.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
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