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Med Combo Query
Hello Doctors,
Can we take nexito 10 and doxepin 10 (Insonmia) together and then taper nexito.Please guide. Regards
Answers (11)
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For insomnia
Clonazepam 0.5 or1 mg+ quitipine25 one is best.
Your medicine is also good.
Why to tapper nexito10 it's minimal dose u can stop if u feel so.
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Sure..
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Yes
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Yes can be taken.
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I can definitely help you over this being a general physician
You can consult with me online on Practo or Contact on eight three one eight four six nine eight eight six for proper diagnosis, conclusion and management
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Need few more details
Kindly connect.
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Yes, escitalopram (Nexito 10) and doxepin (10 mg) can be co-administered with caution in some clinical scenarios, but certain factors must be considered:
1. Mechanism & Use
Escitalopram is a selective serotonin reuptake inhibitor (SSRI) used primarily for anxiety and depression.
Doxepin is a tricyclic antidepressant (TCA) with strong antihistaminic and sedative properties, used in low doses (≤10 mg) for insomnia.
2. Safety Concerns of Combination
Risk of Serotonin Syndrome: Although low, combining SSRIs and TCAs may raise serotonin levels. At low doxepin doses (≤10 mg), this risk is minimal.
QT Prolongation: Both drugs can affect QT interval, especially in higher doses or in predisposed individuals.
Anticholinergic Burden: Doxepin has anticholinergic side effects, so caution in elderly or those with cardiac disease.
3. Tapering Escitalopram
Should only be tapered gradually after clinical stability for 6–12 months.
If tapering is attempted, doxepin may help mitigate sleep issues or anxiety during the withdrawal phase.
Recommendation
Co-administration is clinically acceptable in low doses under physician supervision.
Regular monitoring of side effects, mood, and ECG (if cardiac risk) is advised.
Reference: Harrison’s Manual of Medicine, 20th Ed – Psychopharmacology and antidepressant interactions.
Mark HELPFUL ☺️☺️☺️
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Connect
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Dr. Manoj Kumar
General Physician
10 yrs exp
Dehradun
Need few more details
Kindly consult
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Dr. Anuj Mothsra
General Physician
6 yrs exp
Jhunjhunu
Can help you, kindly consult and provide detailed history for proper diagnosis and further management
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