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Hla b27 positive and then negative
Hello doctor ,
On first test my hla b27 was positive . After sometime on my second test it was negative . I left the treatment and I had tendonitis this week and my doctor suggest to have another test (third test ) of hla b27 which was again negative . This third test was by PCR and first and second was with flowcytometry . Do I have ankylosing spondylitis ?
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HLA B27 is a test to detect ankylosing spondylitis in hereditary pattern that is whether it is coming from your father or mother..
In many cases it is negative, so ankylosing spondylitis is assessed by clinically evaluating you and doing basic xray of the spine and looking for inflammatory markers in the blood like esr or crp. Based on that we decide to label a patient is ankylosing spondylitis.
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Dr. Kiran Reddy Chennuri
Orthopedic surgeon
18 yrs exp
Hyderabad
A diagnosis Ankolysing spondolytis does not just depend on HLA B27 alone. It is a combination of factors such as serology and radiology along with clinical assessment will establish a diagnosis of AS. Usually, an MRI of the SI joint will also help in identifying early changes in the sacroiliac joint. X rays take up to years to manifest as findings.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.