Depressed and alone. Can't what do i do?

Feeling extremely depressed can't move off my bed or truly function . Loss of appetite . Random panic attacks and constantly in a state of anxiety . Randomly burst out crying uncontrollably , thoughts of self harm are hard to keep at bay . I have had such episodes stretching for months before also but always somehow moved on but this time the trigger of all of this is the transition from ending college , the lack of being placed and the most important part that I lost my closest friend in college to rumours as he believes that I said things about him . He has meant the world for me a real long time and the loss of his friendship is something I can't deal with . Im overwhelmed and lonely and constantly told I'm being weak and should get a move on things but I can't What do I do