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Sertraline apathy issue, need better fix
I am a student with recurrent anxiety and depression. I took escitalopram 10mg from January 2024 to April 2025 and did very well. Eight months after stopping, anxiety returned in December 2025 due to my father falling ill. This second episode was fifty percent milder than my first. I started sertraline 50mg which is working well for anxiety and depression.
However sertraline is causing emotional blunting, apathy, anhedonia and low motivation badly hitting my studies. I have no drive or spark to study despite mood being better.
Two weeks ago aripiprazole 2mg was added. Since then I have worse brain fog, lethargy, apathy, small mood highs and lows daily and poor sleep. Day twenty five now with no improvement.
My questions are One:Stop aripiprazole given poor tolerance at lowest dose after twenty five days. Need tapering?
Two : Is bupropion 150mg better augmentation for my apathy, anhedonia and low motivation with sertraline 50mg?
Answers (5)
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Hopefully consulting your psychiatrist who has started these medications will benefit more.
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Please consider switching to escitalopram and stop aripiprazole
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Hi, you should have tried escitalopram as it worked well previously
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Dr. Mohit Bansal
Psychiatrist
6 yrs exp
Faridkot
You can switch completely to bupropion or escitlaopram
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.