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Is Pyrazinmide mandatory for TB treatmnt
My mother is diagnosed with lungs TB and started with AKT4 but soon after a week she experienced extreme nausea and vomiting and weakness. SGOT and SGPT were 350 and 200 respectively. Hence stopped for a week then restarted one drug at a time in 5 day interval. When rifampicin was given she again experienced a little nausea and weakness with slightly increased sgot and sgpt levels which was under control. So doctor suggested to not go with Pyrazinmide which was next drug as he thought it will cause same effect. So now she is having Ethambutol, levoflaxacin, Isoniazid and Rfimapicin. Are these drugs ok? Is Pyrazinmide to be mandatorily given?
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Initial two months of pyrazinamide therapy is mandatory for effective therapy and outcome, in case of drug resistance to pyrazinamide or severe side effects may have to choose an alternate drug
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Hi. I understand your concern. Pyrazinamide is necessary to be added if possible. Without it the duration of treatment may need to be extended. Do a online consult for a detailed analysis of symptoms and reports to suggest you further management plan and treatment prescription for the same
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Yes mandatory..
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Pyrizinamide reduces the total duration of therapy and as well as reduces the chances of drug resistance. Our ancestors used to treat tb with other drugs except pyrizinamide in old times. The duration of therapy at that time used to be greater than 12 months..recently govt has given guidelines for formulating treatment plans without pyrzinamide also.
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there are other drugs in basket to be used if pza is not formed.
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Dr. A Raja Prasanna Kumar
Pulmonologist
44 yrs exp
Hyderabad
Yes,pl.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.