Download FREE Practo app
Get ₹200 HealthCash
High Serum GPT and GOT value
My serum GPT value is 131 and Serum GOT is 65. Currently I am taking ART since 8 years with medicine name TLD. Is it too high value for these tests and what can be cause and remedy.
Answers (20)
Get your queries answered instantly with Care AI FREE
20000+ health queries resolved in last month
If you want to discuss your problem in more detail, feel free to message me on WhatsApp at nine one one nine two five five six nine nine for a detailed free discussion
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Didn't find the answer you are looking for?
Talk to experienced doctor online and get your health questions answered in just 5 minutes.
+124
Your SGPT (ALT) 131 and SGOT (AST) 65 are elevated (approximately 2–3 times the upper limit of normal).
This indicates mild to moderate transaminitis and requires evaluation, but it is not an emergency if you are asymptomatic.
Since you are on TLD for 8 years,medication-related liver enzyme elevation is possible, but after long-term stable therapy, other causes must also be ruled out.
Common causes to consider:
Drug-induced liver injury
Fatty liver disease (very common at this age)
Hepatitis B or C co-infection
Alcohol intake
Important: Do not stop ART on your own.
Next Steps
Recommended evaluation:
Repeat LFT after 2–3 weeks
Hepatitis B surface antigen, Anti-HCV
Ultrasound abdomen (to look for fatty liver) Bilirubin, ALP, INR (to assess severity)
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Get usg done and have a follow up
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Most probably it's due to TLD medicine
Investigation - Hepatitis profile
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Due to meds
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
*Get your CD4 count checked along with Hep A, B , C , D, E tests
*EBV IgM&IgG
*CMV IgM&IgG
*Lipid profile
*CBP, TSH, Ferritin
Ultrasound abdomen
Have LFT tested every week for four weeks to see if it settling. They usually do.
All the best.
www.jgsr-health-education.in
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Liver enzymes are high, can be due to tab TLD or some other cause, get tests done for hepatitis B and C, ultrasound abdomen done and share results.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Your SGPT (131) and SGOT (65) are elevated. SGPT is about 3–4 times normal, so it is moderately high.
Possible causes:
• ART medicines (TLD can sometimes affect liver)
• Fatty liver
• Alcohol intake
• Viral hepatitis (B or C)
• Other medicines or supplements
What to do:
• Do not stop ART on your own
• Repeat LFT after 2–4 weeks
• Check Hepatitis B & C status if not done
• Avoid alcohol and unnecessary medicines
• Do ultrasound abdomen
If values keep increasing or you have jaundice, vomiting, or severe weakness, see your doctor urgently.
Based on your symptoms, this may require proper clinical assessment and prescription. You may book an online consultation with me for detailed evaluation and personalised treatment plan.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Your values:
• Serum GPT (ALT) = 131
• Serum GOT (AST) = 65
Normal range (lab dependent, approx):
• ALT: up to ~40
• AST: up to ~40
So yes — ALT is about 3× upper limit, AST mildly elevated.
This is a moderate liver enzyme elevation, not an emergency, but not normal either.
You are on TLD (Tenofovir + Lamivudine + Dolutegravir) for 8 years.
Possible causes:
1️⃣ ART-related liver enzyme elevation (can occur, though less common after long stable use)
2️⃣ Fatty liver (very common)
3️⃣ Alcohol intake
4️⃣ Viral hepatitis (HBV, HCV)
5️⃣ Recent infection
6️⃣ Gym supplements / herbal meds
7️⃣ Muscle injury (AST can rise with muscle strain)
Important: If bilirubin is normal and you have no jaundice, it is usually not acute liver failure.
Next Steps
You should get:
✔ Repeat LFT after 2–4 weeks
✔ Bilirubin
✔ ALP
✔ GGT
✔ Hepatitis B & C screening
✔ Ultrasound abdomen
Also review:
✔ Alcohol intake
✔ Any new medicines
✔ Gym supplements
Do NOT stop ART on your own.
Stopping ART suddenly is dangerous.
Seek urgent care if:
• Yellow eyes
• Dark urine
• Severe weakness
• Persistent vomiting
Health Tips
✔ Avoid alcohol completely
✔ Avoid unnecessary painkillers
✔ Avoid protein powders / herbal liver tonics
✔ Maintain healthy weight
✔ Stay hydrated
Many mild–moderate liver enzyme elevations in ART patients are reversible once cause is identified.
If you share:
• Your weight
• Alcohol history
• Bilirubin value
• Any abdominal pain
I can help narrow down the most likely cause. Given your long-term ART use, booking an online consultation would help interpret your full liver panel properly and ensure your HIV treatment remains safe and uninterrupted.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Please consult with your physician locally .
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Consult superspecialist like liver specialist.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Serum GPT (ALT) 131 and Serum GOT (AST) 65 are elevated above normal limits. ALT is approximately 3 times the upper normal limit, indicating mild to moderate liver inflammation. This can be due to several causes such as antiretroviral therapy (TLD), fatty liver, alcohol intake, viral hepatitis (HBV/HCV), or other medications. Since you are on ART for 8 years, drug-related liver enzyme elevation is possible but needs proper evaluation before making any changes. It is not dangerously high at present but should not be ignored.
Next Steps
1. Do not stop ART (TLD) on your own.
2. Repeat liver function test (LFT) after 2–3 weeks.
3. Check complete liver profile including bilirubin, ALP, and GGT.
4. Screen for Hepatitis B and C if not done recently.
5. Ultrasound abdomen to rule out fatty liver.
6. Consult your treating physician for evaluation and monitoring.
Health Tips
• Avoid alcohol completely.
• Avoid self-medication and herbal supplements.
• Maintain healthy diet and weight.
• Seek urgent medical attention if you develop yellowing of eyes/skin, severe abdominal pain, persistent vomiting, or dark urine.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Shaikh Huzaif
General Physician
20 yrs exp
Mumbai
Please consult
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Kamal Kumar
General Physician
7 yrs exp
Rewari
Dear Patient,
Your liver enzymes
• SGPT (ALT) = 131 → Moderately elevated
• SGOT (AST) = 65 → Mildly elevated
possible causes include:
• Drug-related liver enzyme elevation
• Fatty liver
• Alcohol intake (if any)
• Viral hepatitis (A, B, C)
• Recent infection or illness
Advice
• Repeat LFT after 2–3 weeks
• Get Ultrasound abdomen
• Test for Hepatitis B & C if not done recently
• Avoid alcohol completely
• Avoid unnecessary medicines/supplements
Do NOT stop ART on your own.
If enzymes rise above 3 times normal or you develop:
• Yellow eyes
• Severe weakness
• Abdominal pain
Seek urgent medical review.
Kindly consult me on Practo with full reports for detailed evaluation and proper management plan.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Ashita Kuruvilla
General Practitioner
8 yrs exp
Kolkata
Few more details needed for further evaluation. Kindly consult
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Sajid Ali
General Practitioner
4 yrs exp
Kanpur
Mostly due TLD medicine
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Gaurav Jaiswal
General Physician
7 yrs exp
Jhansi
Avoid fried and spicy food
Water intake more
Green leafy vegetables more
Fiber meal
Do connect and consult
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Vetsa Sri Krishna Chaitanya
General Physician
7 yrs exp
Rajahmundry
Need a few more details please consult for further evaluation and treatment
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Anuj Mothsra
General Physician
6 yrs exp
Jhunjhunu
Can help you, kindly consult and provide detailed history for proper diagnosis and further management
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Suraj Sharma
General Practitioner
4 yrs exp
Jaipur
Need some more details kindly consult
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Articles you may like
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
The question asked on this page is a free question. You can ask a free health question by downloading the Practo app.
Articles you may like
Tell us what's troubling you
Tell us what's troubling you
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.