High bilirubin levels, known as hyperbilirubinemia, can have various causes. Some of the common ones include:
1.
Liver diseases such as hepatitis, cirrhosis, or liver cancer can cause impaired bilirubin processing and clearance.
2. Hemolytic anemia, a condition in which red blood cells are broken down too quickly, can lead to elevated levels of bilirubin.
3. Gilbert's syndrome, a genetic condition that impairs the liver's ability to process bilirubin, can lead to increased levels of unconjugated bilirubin.
4. Obstruction of the bile ducts, such as by gallstones or tumors, can prevent bilirubin from being excreted from the liver, leading to elevated levels in the blood.
5. Certain medications, such as some antibiotics, antiretrovirals, and chemotherapy drugs, can cause hyperbilirubinemia as a side effect.
6. Inherited disorders such as Crigler-Najjar syndrome and Dubin-Johnson syndrome can lead to impaired bilirubin metabolism and elevated levels in the blood.
It is important to consult with a healthcare provider to determine the underlying cause of high bilirubin levels and to develop an appropriate treatment plan.
Regards,
Dr UN Sahoo (MD)