Your immune response is poor .

A low or negative hepatitis B antibody level even after proper vaccination can happen in a small percentage of people and does not automatically mean something seriously “wrong” with your body. These individuals are called “non-responders” or “hypo-responders.” Common reasons include: * Genetics / individual immune response variation * Obesity, smoking, alcohol use * Diabetes or metabolic syndrome * Increasing age * Incorrect vaccine storage/administration previously * Rarely underlying immune disorders An anti-HBs level of

As if you have a doubt that your immunity is declining..need to do thoroygh examination and investigation to rule out infection ..bre status too needed...if not then..it means you are healthy and out of illness..kindly consult a physician nearby with reports

Hydrate yourself properly Eat green leafy vegetables Consult for further queries

Its varies person to person ,, individual body response to immunity

If you’re looking for proper diagnosis and clear treatment—not confusing or incomplete advice—you can consult me directly. Available on Practo or via WhatsApp: Eight Seven Six Two Seven Four Nine Nine Seven Four This is a paid consultation. I provide structured, step-by-step treatment plans with simple explanations, focused management, and follow-up until recovery. Avoid delays and self-medication—get the right treatment from the start.

It is understandable to feel concerned when your lab results don't show the expected level of immunity after multiple vaccine series. However, what you are describing is a recognized clinical scenario. ​A result of 5 mIU/mL is technically below the 'protective' threshold (usually >10 mIU/mL), which classifies you as a 'Non-Responder' to the standard Hepatitis B vaccine. Here are the most common reasons why this happens: ​The 'Non-Responder' Phenomenon: About 5–10% of healthy individuals do not show a measurable antibody (anti-HBs) response to the standard surface antigen vaccine. This is often due to specific genetic variations in how the immune system recognizes this particular virus. ​Waning Antibody Levels: Even if the vaccine worked 12 years ago, antibody levels naturally decline over time. However, your body may still have 'immune memory' (memory B cells) that could fight the virus if you were ever exposed, even if the blood test shows a low number. ​Factors Affecting Response: Age (response decreases after 40), smoking, a high BMI, or certain chronic underlying conditions can sometimes hinder the body’s ability to produce these antibodies. ​What to do next: Since you have already restarted the 3-dose series, I recommend checking your levels again 1 to 2 months after the final dose. If you remain a non-responder: ​Specialized Vaccines: Discuss with your doctor the possibility of using a different type of Hep B vaccine (such as the adjuvanted Heplisav-B), which is designed specifically to trigger a stronger response in non-responders. ​Screening: Ensure you have been screened for chronic Hepatitis B (HBsAg) or C, as a pre-existing silent infection can sometimes prevent a response to the vaccine. ​Don't be discouraged; for most non-responders, it is a matter of finding the right vaccine protocol rather than a general failure of the immune system.

Please tell detailed history

Some people are naturally low or non responders to the Hepatitis B vaccine despite being otherwise healthy, so this does not automatically mean something is seriously wrong with your body.

Your reports do not necessarily mean that something is seriously wrong with your body. A small percentage of healthy people do not develop high detectable antibody levels even after vaccination, and this can happen due to genetic or immune-response variation. In many cases, repeating the vaccine series or using a different vaccine schedule helps improve immunity. Please do not panic — this condition is manageable and does not automatically mean you have a disease or weak immunity.

The situation you've described is a known clinical phenomenon where an individual is a 'Vaccine Non-responder'. Approximately 5-10% of healthy individuals do not develop a protective antibody titre (>10\text{ mIU/ml}) even after a standard 3-dose Hepatitis B vaccine series. Since your titre is 5 mIU/ml, it is below the protective threshold. This doesn't mean something is 'odd' with your body in a dangerous way, but rather that your immune system's specific pathway for the Hepatitis B surface antigen isn't getting activated effectively by the standard vaccine

Need a few more details please consult for further evaluation and treatment

Need few more details for further evaluation kindly consult

There is genetic variations in response to vaccines. Get yourself tested after finishing current vaccine.  Prior Subclinical infections can also alter response. If again antibody titre is low, discuss with your doctor.

-Your Anti-HBs level of 5 mIU/mL suggests inadequate antibody response after Hepatitis B vaccination -Some individuals are natural low/non-responders despite being otherwise healthy

Immunity usually remains for a year May very from manufacturers

Avoid fried and spicy food Water intake more Do connect and consult

Do consult

Abnormal immune response

Can help you, kindly consult and provide detailed history for proper diagnosis and further management