Dr. Mitesh Shetty

Dr. Mitesh Shetty is a highly distinguished clinician with extensive laboratory expertise in the field of Medical Genetics, with over 22 years of sustained excellence spanning clinical service, counseling, laboratory governance, academic leadership, and transcribes genomics to regular medicine. He is currently serving as the Head of the Department and Consultant – Medical Genetics at Manipal Hospital Old Airport Road, Bangalore.His unique distinction lies in his rare dual role as both a senior clinical geneticist and an actively engaged laboratory leader, who comprehensively oversee a full-spectrum genetic laboratory, encompassing screening investigations, routine diagnostic services, and highly specialised genetic testing. Under his direct supervision, the laboratory delivers services across cytogenetics, biochemical screening, fluorescence in situ hybridisation (FISH), molecular diagnostics, chromosomal microarray analysis, and Next generation sequencing, analysis and reporting, ensuring the highest standards of clinical accuracy, quality assurance, and interpretative excellence.Over the course of his professional career, Dr. Shetty has rendered more than 15,000 clinical evaluation and genetic counseling and has personally supervised, clinically correlated, validated, and signed over 30,000 new born screening reports, 25,000 first / second trimester prenatal screening reports, 3,100 Next-Generation Sequencing (NGS) reports, 3,000 Chromosomal Microarray Analysis (CMA) reports, 2000 Sanger reports and 5000 FISH and 4000 Karyotyping reports. Clinically, Dr. Shetty is a recognised authority in dysmorphology, skeletal dysplasias, neuromuscular disorders—including Duchenne muscular dystrophy and spinal muscular atrophy—and neurodegenerative disorders such as Huntington’s disease. His expertise further extends to the diagnosis and management of chromosomal disorders, genetic haemolytic anaemias, intellectual disability, recurrent pregnancy loss, and prenatal genetic conditions. He is extensively involved in oncogenetic counselling, cancer risk assessment, and pre-marital genetic screening, with particular proficiency in the interpretation of biochemical screening tests, non-invasive prenatal testing (NIPT), CMA, and NGS-based assays.In addition to his clinical leadership, Dr. Shetty has played a pivotal role in establishing and standardising advanced genetic technologies, including exome sequencing integrated with whole-genome CNV backbone analysis, Pre-implantation Genetic Testing (PGT), somatic mutation analysis, sperm aneuploidy testing, and cancer genomic arrays. These initiatives have significantly strengthened the institution’s precision medicine and personalised healthcare capabilities.Dr. Shetty’s academic credentials include an MBBS from Padmashree Dr. D.Y. Patil Medical College, Mumbai, an MSc in Medical Genetics from the University of Glasgow, United Kingdom, and a PhD in Medical Genetics from Manipal University. His research experience spans multiple national and international projects, including his role as a Senior Research Fellow in studies on the genetic control of thalassemia, and as a Medical Research Officer in projects related to cancer genomics and proteomics. His recent work covers a broad spectrum of genetic disorders, including developmental and epileptic encephalopathies, β-thalassemia, and Dravet syndrome.He currently serves as the Course Director for the M.Sc. Genomic Counselling programme and the One-Year Fellowship Programme in Molecular Genetic Pathology, affiliated with Manipal Academy of Higher Education (MAHE). In this capacity, he plays a strategic role in academic leadership, capacity building, and workforce development in the field of medical genetics. His academic contributions further include mentoring PhD and M.Phil. scholars, faculty development initiatives, and curriculum design.Dr. Shetty has an extensive record of publications in peer-reviewed national and international journals and has authored chapters in standard medical textbooks. He has conducted numerous workshops, symposiums, and professional training programmes, including end-to-end hands-on workshops on chromosomal microarray analysis. Notably, he recently conducted a Continuing Medical Education (CME) programme commemorating 25 years of the department, in addition to multiple CMEs organized in association with external committees, aimed at disseminating best practices and advances in clinical genetics.Dr. Shetty has also actively led and conducted in public awareness initiatives focused on Down syndrome, autism, thalassemia, cancer genetics, Prader willi syndrome (PWS), and other rare genetic disorders, reinforcing the institution’s commitment to community engagement and preventive genetics.Fluent in English, Hindi, Kannada, and Tulu, Dr. Mitesh Shetty exemplifies a rare combination of clinical acumen, laboratory governance, academic leadership, and strategic vision, making him an invaluable institutional asset and a national leader in the field of Medical Genetics.Field of ExpertiseMore than 22 years of extensive experience in the field of Medical Genetics Prenatal diagnosis & Genetic counselingGenetic diagnosis of Down syndrome, Autism, β-Thalassemia, Haemophilia, Duchenne muscular dystrophy (DMD) & Spinal muscular atrophy (SMA) etc.Genetic counseling in consanguinity, recurrent abortions, Infertility, Pre- implantation Genetic Screening Test (PGT), Non-Invasive Prenatal Screening (NIPT/NIPS)Expertise in Karyotyping, FISH study, Double/Quadruple study, Chromosomal Microarray & Next Generation Sequencing (NGS)Risk assessment in hereditary cancer disorders like Breast & Ovarian cancer