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Krabeva 400 mg/16 ml Injection
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Krabeva 400 mg/16 ml Injection

Manufactured byBiocon Ltd.
ContainsBevacizumab
Description
Krabeva 400 mg/16 ml Injection is an anticancer medicine that is used alone or in combination with other medicines for the treatment of various types of cancers. This medicine works by inhibiting the blood supply to the tumour, which provides nutrients and oxygen to the cancer cells. Thus it slows down the growth of cancer cells. Krabeva 400 mg/16 ml Injection can show side effects like body ache, sweating, tiredness, diarrhoea, nausea, vomiting, stomach pain, decreased blood cell count, weakness, etc. Consult your doctor if these side effects persist or worsen. Avoid driving vehicles and operating machines after receiving this medicine as it can make you feel dizzy. Krabeva 400 mg/16 ml Injection is administered by a qualified healthcare professional in a clinic or a hospital setting. Your dose and duration of the treatment will be decided based on the severity of your condition. Do not stop receiving this medication without consulting your doctor, as it may worsen your condition. Krabeva 400 mg/16 ml Injection is not recommended if you are allergic to it. Inform your doctor about all your current medications and pre-existing medical conditions before receiving this medicine. This will help your doctor to adjust your dose to avoid undesired effects. Consult your doctor if you are pregnant or are breastfeeding.
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Side effectsConcernsUsageRelated products

Substitutes

List of substitutes for Krabeva 400 mg/16 ml Injection

Avastin 100 mg/4 ml Injection
Roche India
Avastin 400 mg/16 ml Injection
Roche India
Krabeva 100 mg/4 ml Injection
Biocon Ltd.
Bevazza 100 mg/4 ml Injection
Lupin Ltd.
Bevarest-400 Injection
Emcure Pharmaceuticals Ltd.

Side effects

Major & minor side effects for Krabeva 400 mg/16 ml Injection

  • Black or tarry stools
  • Bleeding gums
  • Body aches or pain
  • Burning, numbness, tingling in the arms and feet
  • Chest pain
  • Chills
  • Decreased urine output
  • Fever
  • Irregular breathing
  • Seizures
  • Sore throat
  • Sweating
  • Unusual bleeding or bruising
  • Unusual tiredness and weakness
  • Dizziness
  • Nausea and vomiting
  • Diarrhoea
  • Low blood cell count
  • Change in taste

Uses of Krabeva 400 mg/16 ml Injection

What is it prescribed for?

  • Colorectal Cancer
  • Non-Small Cell Lung Cancer
  • Glioblastoma Multiforme
  • Renal cell carcinoma
  • Cervical cancer
  • Ovarian Cancer
  • Fallopian Tube Cancer
  • Peritoneal Cancer
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Krabeva 400 mg/16 ml Injection can be observed rapidly after intravenous administration.
  • How long do the effects of this medicine last?
    Krabeva 400 mg/16 ml Injection may remain in your body for 120 days.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Krabeva 400 mg/16 ml Injection.
  • Can this medicine be taken during pregnancy?
    Krabeva 400 mg/16 ml Injection is highly unsafe during pregnancy as it can harm your foetus. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Krabeva 400 mg/16 ml Injection is not recommended for use while breastfeeding, and for at least six months after your last dose.

Allergy

Krabeva 400 mg/16 ml Injection is not recommended for use if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.
Warnings for special population

Pregnancy

Krabeva 400 mg/16 ml Injection is highly unsafe during pregnancy as it can harm your foetus. Consult your doctor if you are pregnant.

Breast-feeding

Krabeva 400 mg/16 ml Injection is not recommended for use while breastfeeding, and for at least six months after your last dose.
General warnings

Fistula formation

Krabeva 400 mg/16 ml Injection should be used with caution as it can lead to the formation of fistula (an abnormal connection between two hollow spaces, such as blood vessels, intestines, or other hollow organs) on different organs of the body.

Driving and operating machines

Krabeva 400 mg/16 ml Injection may cause drowsiness, fainting, loss of balance, etc. Therefore, avoid driving vehicles or operating machines if you experience such symptoms while receiving this medicine.

Cardiovascular diseases

Krabeva 400 mg/16 ml Injection should be used with caution if you have pre-existing disorders related to the heart and blood vessels, as this medicine may further worsen your condition.

Use in children

Krabeva 400 mg/16 ml Injection is not recommended for use in children below 18 years of age as the safety and efficacy data are not clinically established.

Surgery

Krabeva 400 mg/16 ml Injection may impair wound healing and increase the risk of other complications. Hence, this medicine is not recommended for at least 28 days after a surgical procedure or until the surgical wound is fully healed.

Bleeding

Krabeva 400 mg/16 ml Injection may increase the risk of bleeding, and it is recommended to discontinue this medicine at least 28 days before surgery. Hence, consult your doctor before undergoing surgery.

Proteinuria

Krabeva 400 mg/16 ml Injection may increase the risk of proteinuria (high levels of protein in the urine). Hence, it should be used with caution, especially if you have kidney problems.

Missed Dose

As Krabeva 400 mg/16 ml Injection is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.

Overdose

As Krabeva 400 mg/16 ml Injection is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by your doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Thalidomide

Deferiprone

Sunitinib

Topotecan

Disease interactions

Hypertension

Krabeva 400 mg/16 ml Injection may cause a severe increase in blood pressure. Hence it should be used with caution if you have hypertension (high blood pressure). Your doctor will monitor your blood pressure periodically during treatment with this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Krabeva 400 mg/16 ml Injection is usually administered by a qualified healthcare professional in the hospital or clinical setting. Consult your doctor if you experience any side effects that persist or worsen. Krabeva 400 mg/16 ml Injection may cause an increase in blood pressure. Hence, monitor your blood pressure periodically while receiving this medicine. This medicine may increase the risk of bleeding and also impair wound healing. Hence inform your doctor if you recently had surgery or are planning to undergo surgery. Use effective contraceptive methods to avoid pregnancy while receiving Krabeva 400 mg/16 ml Injection, as it can harm the developing foetus. Krabeva 400 mg/16 ml Injection may cause ovarian failure, a condition in which the ovaries stop working properly causing fertility problems and symptoms of menopause in women. Hence consult your doctor about the risk of infertility before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
Krabeva 400 mg/16 ml Injection inhibits the formation and growth of blood vessels that bring oxygen and nutrients to cancer cells. This helps in slowing the growth of the cancer cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

VEGF/VEGFR inhibitors, Anticancer drug

Schedule

Schedule H

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https://www.medicines.org.uk/emc/files/pil.3885.pdf>

Medsafe.govt.nz. 2022. [online] Available at: < [Accessed 1 March 2022].

http://medsafe.govt.nz/Consumers/cmi/a/avastin.pdf>

avastin. 2022. Avastin® (bevacizumab) Safety, Side Effects & Patient Financial Support. [online] Available at: < [Accessed 1 March 2022].

https://www.avastin.com/patient/mcrc.html>

Ema.europa.eu. 2022. [online] Available at: < [Accessed 1 March 2022].

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000582/WC500029271.pdf>

Gene.com. 2022. [online] Available at: < [Accessed 1 March 2022].

https://www.gene.com/download/pdf/avastin_prescribing.pdf>
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Information on this page was last updated on 2 Mar 2022

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