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Tuberculoma
My wife was diagnosed with tuberculoma (brain tb) around 19 months ago. Initially medication was started with pyrazinamide 1500 mg rifampin 450 mg isoniazid 450 mg ethambutol 1000 mg and dexamethasone 18 mg for first four months. Then ethambutol was dropped and rest three were continued for next 8 months.
After 1 year, MRI scan showed good progress so pyrazinamide was also dropped and rest two drugs were continued for next 7 months.
Subsequently, latest MRI scan on 15 Sep 2020 has shown an increase in the infection with no major clinical symptoms except mild headaches.
Is it possible that infection can increase inspite of continuing medication as mentioned above. Latest PET scan report is normal.
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Dr. Sudheer Penchala
Neurologist
6 yrs exp
Vijayawada
Rifampicin and isoniazid are not actually good in penetrating the blood brain barrier in the brain,so chances of drug reaching the site is less with these drugs.......where as pyrazinamide is a good in that senario.........that's why when u had 3drugs regimen u had the best response............so consult a Neurologist.......again for drug adjustment
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Dr. Amitabh Gupta
Spine Surgeon
19 yrs exp
Delhi
Need to see Mri both precious and now latest for comment.
Thanks
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Dr. Santhosh R
Neurosurgeon
17 yrs exp
Puducherry
Yes. There are possibilities of recurrence of TB if the persons immunity or low or if the virulence of the Mycobacterium is high.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.