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Flucanozole 50 mg plus antidepressants
I m advised flucanozole 50 mg for 7 days for vaginal thrush.I m taking escitalent plus and desvenlafaxine since last 5 years.
Is it safe to take flucanozole orally for 7 days alongside antidepressants?
Answers (5)
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As a psychiatrist, it is important to consider potential drug interactions between fluconazole and psychotropic medications like escitalopram (Escitalent Plus) and desvenlafaxine.
Fluconazole can inhibit CYP2C19 and CYP3A4, enzymes involved in metabolizing many SSRIs and SNRIs, which can theoretically increase blood levels of these antidepressants. This might slightly enhance side effects such as nausea, dizziness, or rarely, serotonin toxicity—though this is unlikely with short-term low-dose use (50 mg daily for 7 days).
However, such interactions are generally not clinically significant at low doses and for short durations like in this case. Most patients tolerate this combination well without dose adjustments.
Next Steps
Next Step (What should the patient do next?)
You can go ahead with the prescribed fluconazole 50 mg for 7 days if advised by your gynecologist or physician.
Do inform your treating psychiatrist about this temporary medication so they can monitor for any potential interaction symptoms, especially if you notice anything new.
If any side effects like palpitations, agitation, excessive drowsiness, or restlessness occur, consult your doctor immediately.
Health Tips
Helpful Tips / Word of Caution
Avoid alcohol, dehydration, or overexertion during this period to reduce systemic side effects.
Take fluconazole after food to minimize gastric upset.
If you experience mood changes, confusion, or excessive sedation, don’t ignore them—seek review.
Always avoid over-the-counter antifungals without medical advice when on long-term psychiatric medications.
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As per my view, there is no issue in continuing your medications for psychiatric problems with this antifungal medication. Further, when you visit your psychiatrist in follow up, you can discuss this point for your concern. If needed your medications for psychiatric illness will be optimised as per symptoms profile and improvement. Remaining there is no issue in taking these medications along with other medications that you mentioned
Next Steps
you continue your medication
Health Tips
continue DBR, sleep hygiene, daily activity schedule along with medication
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Dr. Shailaja Bandla
Psychiatrist
19 yrs exp
Vijayawada
Hi..You can take fluconazole 50 mg with desvenlafaxine or escitalopram, but with some caution.
Fluconazole may slightly increase escitalopram levels, so your doctor may monitor for side effects.
When taking escitalopram and desvenlafaxine together, there's a small risk of too much serotonin.
Watch out for signs like restlessness, sweating, or fast heartbeat—report them if they occur.
Overall, the combination is usually safe if taken as prescribed and under medical supervision.
Consult online for further questions
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Dr. Panna Sharma
Psychiatrist
10 yrs exp
New Delhi
Fluconazole can increase the levels of desvenlafaxine and escitalopram. So if you are on high doses of desvenlafaxine and escitalopram then you can decrease the dose
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Dr. Amit Kumar Patel
Psychiatrist
7 yrs exp
Rewa
You mentioned you're taking fluconazole 50 mg for 7 days for vaginal thrush, while also being on Escitalent Plus and Desvenlafaxine for the past 5 years. It's good that you're checking for safety.
In many cases, fluconazole can be taken with antidepressants, but since you're on long-term psychiatric medication, interactions or side effects can vary from person to person. Monitoring is always advised.
👉 For safe, personalized guidance, I recommend you consult me directly here:
https://www.practo.com/rewa/doctor/amit-kumar-patel-generalphysician
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