CML (bcr abl)

2025-04-07 07:36:54
My father got diagnosed with cml in June 2024 and started with dasatinib but due to continuous low blood counts switched to imatinib. Now after being 5 months on imatinib bcr abl increases from 0.3% to 1.3%. Doctor said change in value is due to different lab used and not to worry. He advised next bcr abl after 3 months. I am worried what if bcr abl keeps on increasing and disease progress. All the other blood counts are in normal range. Please help
49 Views
Can help you with the next course of action and treatment plan. Kindly consult via whatsapp at nine zero two nine six zero zero four seven zero.

Answered2025-04-20 15:32:26

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Didn't find the answer you are looking for?

Talk to experienced doctor online and get your health questions answered in just 5 minutes.

+109
Consult with a doctor
Online now
Consult online

Answered2025-04-11 15:48:37

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

You will need to consult an oncologist

Answered2025-04-11 06:16:34

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Don't worry as you are on medication.

Answered2025-04-11 05:20:27

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Continue consulting with hemato-oncologist.

Answered2025-04-11 05:01:40

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Need evaluation

Answered2025-04-11 04:04:12

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Need to look at pt overall improvement before coming into conclusion about how to proceed
Next Steps
Consult a specialist

Answered2025-04-10 13:19:53

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Hello Thank you for sharing your concerns about your father’s CML (BCR-ABL) status. While the increase from 0.3% to 1.3% could be due to lab variability as suggested by the doctor, it is important to monitor this trend closely. CML management relies heavily on achieving and maintaining molecular response, and any upward trend in BCR-ABL levels should be evaluated carefully to rule out resistance or suboptimal treatment response.  Since your father has already switched therapies due to tolerability issues, a detailed review of his case—including possible mutation testing or dose adjustments—may be necessary. I strongly recommend a **consultation with a CML specialist** to ensure the best course of action.  For further discussion or to schedule an appointment, you can reach me on WhatsApp at **Eight Zero Zero Nine Eight Two One Three Three Two**. Early intervention can make a significant difference in long-term outcomes. 

Answered2025-04-10 10:16:44

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Oncologist consultation.

Answered2025-04-10 07:38:35

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Consult from hemato oncologist. Follow whatever been adviced.

Answered2025-04-10 06:27:36

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Repeat bcr abl.
Next Steps
Consult oncologist

Answered2025-04-10 05:49:57

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Hi, When we look at CML and response to treatment we assess a few things 1. Molecular response : BCR ABL levels 2. Hematological response : based on CBC and peripheral smear 3. Cytological response: based on a bone marrow aspirate At around 6 months of treatment we aim for a BCR ABL of less than 1% as optimal. So if you are worried about the rising signals, you should ask the doctor to suggest the standard lab he/she prefers. Get it repeated. (Generally for certain tests, you need good labs and the nearest lab might not be the best source)
Next Steps
Consult if required

Answered2025-04-10 05:45:45

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Do connect and consult

Answered2025-04-10 04:47:25

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Need few more details Kindly consult

Answered2025-04-12 05:45:43

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Need few more details for proper evaluation. Kindly consult

Answered2025-04-11 18:05:37

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

If you require assistance or have any health concerns, feel free to reach out for a consultation. Your well-being is my priority, and i'm here to support you on your health journey.

Answered2025-04-11 10:17:08

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Please continue to consult with Haematologist

Answered2025-04-11 04:03:45

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Kindly connect

Answered2025-04-11 03:32:44

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Need to connect immediately

Answered2025-04-10 21:11:36

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

You should visit an Oncologist

Answered2025-04-10 12:41:30

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Kindly consult

Answered2025-04-10 11:59:47

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Oncologist opinion

Answered2025-04-10 10:16:02

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Take oncologist opinion

Answered2025-04-10 09:57:19

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Kindly consult

Answered2025-04-10 08:43:20

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Your consultant is right. Please follow his advice

Answered2025-04-10 08:15:51

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Oncology consultation

Answered2025-04-10 07:44:10

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Take oncologist opinion

Answered2025-04-10 06:33:45

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Please consult

Answered2025-04-10 05:42:57

Was this answer useful

Not finding what you need? Ask Practo AI

FREE

Chat with Practo AI on Whatsapp

Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.