Download FREE Practo app
Get ₹200 HealthCash
CML (bcr abl)
My father got diagnosed with cml in June 2024 and started with dasatinib but due to continuous low blood counts switched to imatinib. Now after being 5 months on imatinib bcr abl increases from 0.3% to 1.3%. Doctor said change in value is due to different lab used and not to worry. He advised next bcr abl after 3 months. I am worried what if bcr abl keeps on increasing and disease progress. All the other blood counts are in normal range. Please help
Answers (28)
Didn't find the answer you are looking for?
Talk to experienced doctor online and get your health questions answered in just 5 minutes.
Hello
Thank you for sharing your concerns about your father’s CML (BCR-ABL) status. While the increase from 0.3% to 1.3% could be due to lab variability as suggested by the doctor, it is important to monitor this trend closely. CML management relies heavily on achieving and maintaining molecular response, and any upward trend in BCR-ABL levels should be evaluated carefully to rule out resistance or suboptimal treatment response.
Since your father has already switched therapies due to tolerability issues, a detailed review of his case—including possible mutation testing or dose adjustments—may be necessary. I strongly recommend a **consultation with a CML specialist** to ensure the best course of action.
For further discussion or to schedule an appointment, you can reach me on WhatsApp at **Eight Zero Zero Nine Eight Two One Three Three Two**. Early intervention can make a significant difference in long-term outcomes.
Answered
Let others know if this answer was helpful
Hi,
When we look at CML and response to treatment we assess a few things
1. Molecular response : BCR ABL levels
2. Hematological response : based on CBC and peripheral smear
3. Cytological response: based on a bone marrow aspirate
At around 6 months of treatment we aim for a BCR ABL of less than 1% as optimal. So if you are worried about the rising signals, you should ask the doctor to suggest the standard lab he/she prefers. Get it repeated.
(Generally for certain tests, you need good labs and the nearest lab might not be the best source)
Next Steps
Consult if required
Answered
Let others know if this answer was helpful
Tell us what's troubling you
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.