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Syndopa CR Tablet
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Syndopa CR Tablet

Manufactured bySun Pharma Laboratories Ltd.
ContainsLevodopa (200 mg) + Carbidopa (50 mg)
Description
Syndopa CR Tablet is a combination medicine that consists of Levodopa and Carbidopa. It is used to treat the symptoms of Parkinson's disease (a brain disorder that affects movement with symptoms such as tremors, shakiness, stiffness, difficulty in walking, impaired balance and coordination, etc.). Syndopa CR Tablet works by enhancing the action of dopamine, a chemical messenger that is responsible for information transfer in the brain, which controls movement and coordination. Syndopa CR Tablet may cause side effects like nausea, vomiting, fatigue, constipation, dry mouth, loss of appetite, unusual dreams, trouble sleeping, etc. Consult your doctor if these side effects persist or worsen. Avoid driving vehicles or operating machines after taking this medicine, as it can make you feel dizzy. Syndopa CR Tablet may be taken with or without food as directed by your doctor. The dose and duration of treatment will be decided by your doctor based on the severity of your condition. Take it at the same time every day to maintain a constant level of medicine in your body. Do not stop taking this medicine without consulting your doctor, as your symptoms could become worse. Syndopa CR Tablet is not recommended for use if you are allergic to it. Inform your doctor if you have depression, other mental conditions, liver or kidney problems, or any other health conditions before taking this medicine. Inform your doctor about all your current medicines to avoid any undesired effects. Syndopa CR Tablet is not recommended for use in children below 18 years of age as the safety and efficacy data are not clinically established. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Syndopa CR Tablet

  • Dizziness
  • Headache
  • Depression
  • Hallucinations
  • Dry mouth
  • Nausea and Vomiting
  • Uncontrolled body movements
  • Confusion
  • Abnormal dreams
  • Trouble sleeping
  • Loss of appetite
  • Fatigue

Uses of Syndopa CR Tablet

What is it prescribed for?

  • Parkinson's Disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Syndopa CR Tablet can be observed within an hour.
  • How long do the effects of this medicine last?
    The time duration for which Syndopa CR Tablet remains active in your body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with Syndopa CR Tablet as it may increase the risk of side effects like depression and impairment of judgment, thinking, and psychomotor skills.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Syndopa CR Tablet.
  • Can this medicine be taken during pregnancy?
    Syndopa CR Tablet is generally not recommended for use during pregnancy as animal studies indicate that it may harm the developing foetus. Hence, consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Syndopa CR Tablet is not recommended for use while breastfeeding as it is not known if this medicine passes into breastmilk. Consult your doctor if you are breastfeeding.

Allergy

Avoid taking Syndopa CR Tablet if you are allergic to this medicine. Seek medical attention if you experience symptoms such as skin rash, hives (itchy, painful eruptions that sting), swelling (especially of the face, lips, tongue, etc.), breathing difficulty, etc.

Narrow angle glaucoma

Narrow-angle glaucoma is a condition in which pressure inside your eyes increases. It occurs due to fluid build-up caused by blocked drainage canals (the structure inside the eye that allows fluid to drain normally from the eye). Syndopa CR Tablet is not recommended for use if you have narrow-angle glaucoma as it may increase the risk of mydriasis (a condition in which the pupil of the eye gets widened) due to increased eye pressure.

Nonselective monoamine oxidase inhibitors (MAOIs)

Nonselective monoamine oxidase inhibitors (MAOIs) are a class of medicine used in the treatment of depression. Syndopa CR Tablet is not recommended for use if you are taking nonselective monoamine oxidase inhibitors (MAOIs) or have taken these medicines in the past 14 days.

Malignant Melanoma

Malignant melanoma is a type of skin cancer. Syndopa CR Tablet may activate a malignant melanoma. Hence, it is not recommended for use if you have suspicious, undiagnosed skin lesions (a part of the skin that has an abnormal growth or appearance) or a history of malignant melanoma.
Warnings for special population

Pregnancy

Syndopa CR Tablet is generally not recommended for use during pregnancy as animal studies indicate that it may harm the developing foetus. Hence, consult your doctor if you are pregnant.

Breast-feeding

Syndopa CR Tablet is not recommended for use while breastfeeding as it is not known if this medicine passes into breastmilk. Consult your doctor if you are breastfeeding.
General warnings

Falling asleep during daily activities

Syndopa CR Tablet should be used with caution due to the increased risk of drowsiness. It may also cause you to fall asleep during daily activities, rarely without awareness or warning signs. Hence, avoid performing activities that require high mental alertness like driving vehicles or operating machines while taking this medicine.

Compulsive behaviours

Syndopa CR Tablet should be used with caution due to the increased risk of impulsive or compulsive behaviour like the intense urge to gamble, binge eating, or spend money. Report such unusual symptoms to your doctor on priority.

Liver disorders

Syndopa CR Tablet should be used with extreme caution if you have liver problems as this medicine is broken down in the liver. If your liver is not working properly, it may cause an accumulation of this medicine, resulting in toxicity. Your doctor may suggest tests to monitor your liver function while you are taking this medicine.

Kidney Disorders

Syndopa CR Tablet should be used with caution if you have kidney problems as this medicine is filtered and excreted through your kidneys. If your kidneys are not working properly, it may lead to the accumulation of this medicine in the body and increase the risk of undesired effects. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your clinical condition.

Use in children

Syndopa CR Tablet is not recommended for use in children less than 18 years of age as the safety and efficacy data are not clinically established.

Bronchospasm

Syndopa CR Tablet may cause bronchospasm (narrowing of the airways). Hence, it is not recommended for use if you have respiratory conditions that cause narrowing of the airways and breathing difficulties, such as asthma and COPD (Chronic Obstructive Pulmonary Disease).

Low blood pressure levels

Syndopa CR Tablet should be used with caution if you have hypotension (low blood pressure) or taking blood pressure-lowering medicines, as it may result in a significant drop in blood pressure when standing up.

Gastrointestinal bleeding

Syndopa CR Tablet may cause bleeding in the stomach and intestine. Hence, it should be used with caution if you have a history of stomach and intestinal ulcers or bleeding.

Missed Dose

Take the missed dose of Syndopa CR Tablet as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek Never take more than the prescribed dose. Seek emergency medical treatment in case of an overdose of Syndopa CR Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with Syndopa CR Tablet as it may increase the risk of side effects like depression and impairment of judgment, thinking, and psychomotor skills.
Interaction with Medicine

Nitrofurantoin

Amiodarone

Captopril

5-Hydroxytryptophan

Alprazolam

Atorvastatin

Furosemide

Droxidopa

Disease interactions

Psychosis

Psychosis is a mental condition that causes abnormal thinking and perceptions. The symptoms include confusion and hallucination. Syndopa CR Tablet should be used with extreme caution if you have a history of psychosis as it may aggravate such conditions. Hallucinations and psychotic-like behaviour have been reported with the use of this medicine.

Depression

Syndopa CR Tablet may cause depression and suicidal tendencies. Hence this medicine should be used with extreme caution if you have depression as it may further worsen your condition. Consult your doctor immediately if you experience changes in mood and behaviour or develop thoughts of self-harm while taking this medicine.

Neuroleptic Malignant Syndrome

Neuroleptic malignant syndrome is a rare life-threatening condition characterised by fever, an abnormally high body temperature, muscle rigidity, altered mental status, irregular pulse or blood pressure, etc. Syndopa CR Tablet is not recommended for use if you have neuroleptic malignant syndrome as it may further worsen your condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Syndopa CR Tablet may be taken with or without food, as advised by your doctor. Do not break, chew, or crush the tablet in your mouth. Swallow as a whole with a sufficient amount of water. Avoid taking more or less than the recommended dose. Consult your doctor if you experience any undesirable effects that persist or worsen. Syndopa CR Tablet can cause drowsiness and rarely sudden sleep episodes without warnings. Hence, avoid performing activities that require mental alertness such as driving vehicles or operating machines while you are taking this medicine. Syndopa CR Tablet may increase the risk of depression and suicidal tendencies. Hence, consult your doctor immediately if you experience changes in mood and behaviour or develop suicidal thoughts.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Syndopa CR Tablet is a combination medicine that consists of Levodopa and Carbidopa. Levodopa gets converted into dopamine (a chemical messenger) in the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents the breakdown of Levodopa in the bloodstream, thus increasing the amount of Levodopa available for transport to the brain.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Dopaminergic Antiparkinsonism agents

Schedule

Schedule H

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 17 December 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/017555s069lbl.pdf>

Dailymed.nlm.nih.gov. 2021. DailyMed - CARBIDOPA AND LEVODOPA tablet. [online] Available at: < [Accessed 17 December 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a355d5f2-407d-40fa-a374-b3632261ea4a>

Drugs, H., 2021. Levodopa and Carbidopa: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 17 December 2021].

https://medlineplus.gov/druginfo/meds/a601068.html>
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Information on this page was last updated on 17 Feb 2022

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