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Syndopa 275 Tablet

Manufactured bySun Pharma Laboratories Ltd.
ContainsLevodopa (250 mg) + Carbidopa (25 mg)
Description

Syndopa 275 Tablet is a combination medicine used to treat the symptoms of Parkinson's disease and Parkinson's-like symptoms which are associated with some other diseases. These may include shakiness, stiffness, and slowness of movement. These symptoms are usually caused by a lack of dopamine, a natural substance present in the brain.

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Side effects

Major & minor side effects for Syndopa 275 Tablet

  • Dizziness
  • Headache
  • Depression
  • Hallucinations
  • Dry mouth
  • Nausea and Vomiting
  • Uncontrolled body movements
  • Fainting
  • Confusion
  • Feeling sad or empty
  • Abdominal or stomach pain
  • Irregular heartbeat
  • Fever

Uses of Syndopa 275 Tablet

What is it prescribed for?

  • Parkinson's Disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 15 minutes of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 5 to 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to levodopa, carbidopa, or any other inactive ingredients present along with these medicines.

Narrow angle glaucoma

This medicine is not recommended for use in patients with a known history of narrow-angle glaucoma due to the increased risk of worsening of the patient's condition.

Nonselective monoamine oxidase inhibitors (MAOIs)

This medicine is not recommended for use in patients who are taking nonselective monoamine oxidase inhibitors (MAOIs) or have taken these medicines in the past 14 days due to the increased risk of severe drug-drug interactions. It is advised that patients should inform the doctor about all their current medicines including herbs and supplements before beginning therapy with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Falling asleep during daily activities

This medicine should be used with caution due to the increased risk of side effects such as dizziness, fainting, and drowsiness. This may cause you to fall asleep during your day-to-day activities. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while taking this medicine.

Compulsive Behaviors

This medicine should be used with caution due to the increased risk of impulsive or compulsive behaviors. These may include an intense urge to gamble, binge eat, or spend money. Close monitoring of the patients for any change in behavior and mood is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver Diseases

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney Diseases

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Cardiovascular diseases

This medicine should be used with caution in patients suffering from cardiovascular diseases due to the increased risk of severe adverse effects. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in Pediatrics

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Hallucinations

This medicine should be used with caution due to an increased risk of severe side effects such as hallucinations, psychotic episodes, and confusion. The risk is especially higher in the elderly patients. Close monitoring of the patients for any changes in mood and behavior is recommended during treatment with this medicine. Any unusual symptoms should be reported to the doctor on priority. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Low blood pressure levels

This medicine may increase the risk of orthostatic hypotension, a condition where the blood pressure drops suddenly when the patient stands up from a sitting or a lying position. This risk is especially higher in patients receiving high blood pressure medicines and elderly patients. Close monitoring of blood pressure may be necessary for such patients based on the clinical condition. Patients are advised to get up slowly from a sitting or a lying position to avoid fainting and falling. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Nitrofurantoin

Amiodarone

Captopril

5-Hydroxytryptophan

Alprazolam

Atorvastatin

Furosemide

Droxidopa

Disease interactions

Glaucoma

This medicine is not recommended for use in patients with a known history of narrow-angle glaucoma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Psychosis

This medicine is not recommended for use in patients with a known history of psychotic disorders due to the increased risk of worsening of the patient's condition. Close monitoring of the patients for any changes in behavior or mood may be necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Depression

This medicine should be used with extreme caution in patients with a known history of depression due to the increased risk of worsening of the patient's condition. Patients should be monitored closely for any changes in behavior and mood. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Neuroleptic Malignant Syndrome

This medicine is not recommended for use in patients with a history of Neuroleptic Malignant Syndrome due to the increased risk of severe side effects. These side effects may include altered mental status, a very high body temperature, irregular pulse or blood pressure, etc. Close monitoring of the patients for any unusual symptoms is necessary. Replacement with a suitable alternative may be considered based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food, as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Levodopa gets converted into dopamine in the brain and relieves the symptoms of Parkinson's disease. Carbidopa prevents the breakdown of levodopa in the bloodstream and the stomach, which is effective in increasing the amount of levodopa available for transport to the brain. Their combination is thus better effective for treating the symptoms of Parkinson's disease.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Dopaminergic Antiparkinsonism agents

Schedule

Schedule H

DailyMed - Carbidopa and levodopa tablet [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 7 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a355d5f2-407d-40fa-a374-b3632261ea4a

Levodopa and Carbidopa: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 7 August 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a601068.html

[Internet]. Db.cbg-meb.nl. 2018 [cited 7 August 2018]. Available from:

https://db.cbg-meb.nl/Pars/h114255.pdf

[Internet]. Medicines.org.uk. 2018 [cited 7 August 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.7810.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 7 August 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/017555s069lbl.pdf

[Internet]. Medisa.com. 2018 [cited 7 August 2018]. Available from:

http://www.medisa.com/client_docs/Sinemet_PI.pdf
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Information on this page was last updated on 7 Sep 2018

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