Denfos 70 mg Tablet

Manufactured byDr. Reddys Laboratories Ltd.
ContainsAlendronate
Description

Denfos 70 mg Tablet is used to treat or prevent osteoporosis in postmenopausal women. It is also used for the prevention and treatment of osteoporosis in men and women who are on corticosteroid therapy. This medicine can also be used to treat Paget's disease of bone, a condition in which the bones are weak, thin, deformed, and easily fractured.

Side effects

Major & minor side effects for Denfos 70 mg Tablet

  • Hypersensitivity
  • Abdominal pain
  • Nausea and vomiting
  • Heartburn
  • Difficulty with swallowing
  • Irregular heartbeat
  • Loss of appetite
  • Loosening of the teeth
  • Joint or muscle pain
  • Swelling of ankles or feet
  • Flu like symptoms

Uses of Denfos 70 mg Tablet

What is it prescribed for?

  • Osteoporosis
  • Paget's disease
Read More
Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 3 weeks of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 12-30 weeks.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to alendronate or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Severe bone, joint and/or muscle pain

This medicine may cause severe bone, joint, and/or muscle pain. Report any such symptoms to the doctor on priority. Your doctor may advise you to discontinue therapy based on your clinical condition.

Thigh bone fracture

Treatment with Denfos 70 mg Tablet may increase the risk of thigh bone fracture. Care should be taken to avoid any falls or other trauma to reduce this risk.

Use in pediatrics

This medicine is not recommended for use in children or adolescents.

Missed Dose

If a dose of once-daily Denfos 70 mg Tablet is missed, do not take it later in the day; skip the dose and follow the regular dosing schedule next morning. Do not double the dose to make up for the missed one. If the once a week dose of Denfos 70 mg Tablet is missed, take the dose next morning and continue with the regular dosing schedule of one tablet once a week.

Overdose

If an overdose of this medicine is suspected, give a full glass of milk to the patient and seek emergency medical treatment or contact the doctor immediately.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Gentamicin

NSAIDs

Deferasirox

Etelcalcetide

Disease interactions

Osteonecrosis of the jaw (ONJ)

This medicine should be used with caution in patients undergoing invasive dental procedures due to the increased risk of osteonecrosis of the jaw (ONJ). Therapy with the medicine may need to be discontinued based on the clinical condition of the patient.

Renal Dysfunction

Denfos 70 mg Tablet is not recommended for use in patients with creatinine clearance less than 35 ml/min due to the increased risk of acute renal failure. Close monitoring of kidney function is necessary during treatment with this medicine.

Hypocalcemia

Denfos 70 mg Tablet is not recommended for treating osteoporosis in patients with decreased calcium levels (hypocalcemia). Calcium and vitamin D levels should be checked before starting therapy with this medicine. It is also important to continue appropriate supplementation of calcium and vitamin D during treatment with this medicine.

Upper gastrointestinal mucosal irritation

Denfos 70 mg Tablet may cause upper gastrointestinal mucosal irritation and increase the risk of gastric ulcers and bleeding. It is advised to take the tablet along with a full glass of water and stand or sit upright for at least 30 minutes after the dose to reduce the chances of these side effects. Therapy should be discontinued if the patient experiences any difficulty in swallowing or persistent abdominal pain. Report any such symptoms to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.

Asthma

Caution is advised while using this medicine in patients with asthma due to the increased risk of worsening of the patient's condition. Close monitoring of such patients for any adverse effects is necessary during treatment with this medicine.

Aspiration

Denfos 70 mg Tablet oral solution is not recommended for use in patients with obstruction of the gastrointestinal tract due to the increased risk of aspiration.
Food interactions
The desired effects of Denfos 70 mg Tablet will not be achieved if it is taken along with food. It is advised to take this medicine first thing in the morning and at least 30 minutes before eating or drinking anything.
The combined use of Denfos 70 mg Tablet and products containing calcium, magnesium, aluminum, or iron may reduce the effectiveness of this medicine. It is recommended not to take such products for at least 30 minutes after taking Denfos 70 mg Tablet. It is advised that you inform the doctor about all your medicines including herbs and supplements before beginning treatment with Denfos 70 mg Tablet to avoid such interactions.
Lab interactions
Information not available.
Take Denfos 70 mg Tablet as instructed by the doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken in morning

Does not cause sleepiness

How it works
Denfos 70 mg Tablet increases bone thickness and reduces the chances of bone breakage.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Bisphosphonates

Schedule

Schedule H

Alendronate: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 18 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a601011.html

DailyMed - ALENDRONATE SODIUM- alendronate sodium tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 18 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f9a2d4-9783-4a5e-8634-b6c8c45afb1d&audience=consumer

[Internet]. 2017 [cited 18 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.28960.latest.pdf

Alendronic acid - DrugBank [Internet]. Drugbank.ca. 2017 [cited 18 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00630

Alendronate (substance) [Internet]. Snomedbrowser.com. 2017 [cited 18 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/96290008

TOXNET [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 18 August 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~YF34tf:4
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