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Denfos 10 mg Tablet

Manufactured by: Dr. Reddys Laboratories Ltd.
Composition: Alendronate
Prescription Required: Yes
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Description

Denfos 10 mg Tablet is used to treat or prevent osteoporosis in postmenopausal women. It is also used for the prevention and treatment of osteoporosis in men and women who are on corticosteroid therapy. This medicine can also be used to treat Paget's disease of bone, a condition in which the bones are weak, thin, deformed, and easily fractured.

Side effects

Major & minor side effects for Denfos 10 mg Tablet

  • Hypersensitivitysevererare
  • Abdominal painsevere
  • Nausea and vomiting
  • Heartburnsevere
  • Difficulty with swallowingsevere
  • Irregular heartbeatsevere
  • Loss of appetite
  • Loosening of the teethsevere
  • Joint or muscle painsevere
  • Swelling of ankles or feetsevere
  • Flu like symptomssevere
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Denfos 10 mg Tablet

Onset of action

The effect of this medicine can be observed within 3 weeks of administration of the dose.

Duration of effect

The effect of this medicine lasts for an average duration of 12-30 weeks.

Safe with alcohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendencies were reported.

Usage in pregnancy?

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Usage while breast-feeding?

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Substitutes

List of substitutes for Denfos 10 mg Tablet

Below is the list of medicines, which have the same composition, strength and form as Denfos 10 mg Tablet, and hence can be used as its substitute.
Alenost 10 mg Tablet
Macleods Pharmaceuticals Pvt. Ltd.
Osteofos 10 mg Tablet
Cipla Ltd.
Restofos 10 mg Tablet
Sun Pharma Laboratories Ltd.

What is it prescribed for?

Uses of Denfos 10 mg Tablet

  • Osteoporosis

    Denfos 10 mg Tablet is used in the prevention and treatment of osteoporosis in postmenopausal women. It can also be used to treat osteoporosis in men and to treat or prevent osteoporosis in men and women who are using corticosteroids.

  • Paget's disease

    Denfos 10 mg Tablet is used in the treatment of Paget's disease, a condition which is characterized by localized bone deformities.

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When not to use?

Contraindications of Denfos 10 mg Tablet

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to alendronate or any other components present along with it.

Dosage

  • Missed Dose

    If a dose of once-daily Denfos 10 mg Tablet is missed, do not take it later in the day; skip the dose and follow the regular dosing schedule next morning. Do not double the dose to make up for the missed one. If the once a week dose of Denfos 10 mg Tablet is missed, take the dose next morning and continue with the regular dosing schedule of one tablet once a week.

  • Overdose

    If an overdose of this medicine is suspected, give a full glass of milk to the patient and seek emergency medical treatment or contact the doctor immediately.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Instructions

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

  • Gentamicinmoderate
  • NSAIDsmoderate
  • Deferasiroxsevere
  • Etelcalcetidesevere

Disease interactions

  • Osteonecrosis of the jaw (ONJ)

    severe
    This medicine should be used with caution in patients undergoing invasive dental procedures due to the increased risk of osteonecrosis of the jaw (ONJ). Therapy with the medicine may need to be discontinued based on the clinical condition of the patient.

  • Renal Dysfunction

    moderate
    Denfos 10 mg Tablet is not recommended for use in patients with creatinine clearance less than 35 ml/min due to the increased risk of acute renal failure. Close monitoring of kidney function is necessary during treatment with this medicine.

  • Hypocalcemia

    severe
    Denfos 10 mg Tablet is not recommended for treating osteoporosis in patients with decreased calcium levels (hypocalcemia). Calcium and vitamin D levels should be checked before starting therapy with this medicine. It is also important to continue appropriate supplementation of calcium and vitamin D during treatment with this medicine.

  • Upper gastrointestinal mucosal irritation

    severe
    Denfos 10 mg Tablet may cause upper gastrointestinal mucosal irritation and increase the risk of gastric ulcers and bleeding. It is advised to take the tablet along with a full glass of water and stand or sit upright for at least 30 minutes after the dose to reduce the chances of these side effects. Therapy should be discontinued if the patient experiences any difficulty in swallowing or persistent abdominal pain. Report any such symptoms to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.

  • Asthma

    moderate
    Caution is advised while using this medicine in patients with asthma due to the increased risk of worsening of the patient's condition. Close monitoring of such patients for any adverse effects is necessary during treatment with this medicine.

  • Aspiration

    severe
    Denfos 10 mg Tablet oral solution is not recommended for use in patients with obstruction of the gastrointestinal tract due to the increased risk of aspiration.

Food interactions

  • The desired effects of Denfos 10 mg Tablet will not be achieved if it is taken along with food. It is advised to take this medicine first thing in the morning and at least 30 minutes before eating or drinking anything.
  • The combined use of Denfos 10 mg Tablet and products containing calcium, magnesium, aluminum, or iron may reduce the effectiveness of this medicine. It is recommended not to take such products for at least 30 minutes after taking Denfos 10 mg Tablet. It is advised that you inform the doctor about all your medicines including herbs and supplements before beginning treatment with Denfos 10 mg Tablet to avoid such interactions.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take Denfos 10 mg Tablet as instructed by the doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Breast-feeding

    - This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General warnings

  • Severe bone, joint and/or muscle pain

    - This medicine may cause severe bone, joint, and/or muscle pain. Report any such symptoms to the doctor on priority. Your doctor may advise you to discontinue therapy based on your clinical condition.

  • Thigh bone fracture

    - Treatment with Denfos 10 mg Tablet may increase the risk of thigh bone fracture. Care should be taken to avoid any falls or other trauma to reduce this risk.

  • Use in pediatrics

    - This medicine is not recommended for use in children or adolescents.

Other details

  • To be taken on an empty stomach
  • To be taken in morning
  • Does not cause sleepiness

How it works

Denfos 10 mg Tablet increases bone thickness and reduces the chances of bone breakage.

Legal Status

Approved
Approved
Approved
Approved

Classification

Category
Bisphosphonates
Schedule
Schedule H

References

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Information on this page was last updated on 31 Aug 2017

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.