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Coversyl-AM 8/10 Tablet
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Coversyl-AM 8/10 Tablet

Manufactured bySERDIA PHARMACEUTICALS (INDIA) PVT. LTD
ContainsAmlodipine (10 mg) + Perindopril (8 mg)
Description
Coversyl-AM 8/10 Tablet is a combination of Amlodipine and Perindopril. It is used in the treatment of hypertension (high blood pressure) and stable coronary artery disease (a condition where the blood flow to the heart is blocked or restricted). This medicine works by relaxing your blood vessels and enables smooth blood flow, thus controls your blood pressure. It also reduces the risk of heart attack or stroke by making it easier for your heart to pump blood throughout your body. Coversyl-AM 8/10 Tablet shows some common side effects like swelling in your ankles or feet (oedema), dizziness, back pain, cough, decreased blood pressure, etc. These side effects are temporary and will go away with time. However, if you have persistent vomiting or diarrhoea, as well as excessive sweating, you should see a doctor. Coversyl-AM 8/10 Tablet should be taken before your meal or as advised by your doctor. Take this medicine at the same time every day to avoid any missed dose. Even if you feel better or your blood pressure appears to be under control, do not stop taking it. Abrupt discontinuation may lead to side effects or a sudden increase in your blood pressure. This medicine is safe for long-term use. Coversyl-AM 8/10 Tablet is only recommended if you are 18 years or above. Inform your doctor if you have any history of kidney, liver, and heart problems, or any other condition. This medicine is not recommended if you are pregnant as it may cause harm to your unborn foetus, especially during the second and third trimesters. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Coversyl-AM 8/10 Tablet

  • Headache
  • Dizziness
  • Cough
  • Weakness
  • Diarrhoea
  • Stomach pain
  • Back pain
  • Ringing or buzzing in the ears
  • Decrease in blood pressure
  • Vomiting
  • Swelling in your ankles or feet

Uses of Coversyl-AM 8/10 Tablet

What is it prescribed for?

  • Hypertension
  • Stable Coronary Artery Disease
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Coversyl-AM 8/10 Tablet starts to work in your body within a few hours and reduces high blood pressure. However, to see its full effect, you need to take this medicine for at least a month.
  • How long do the effects of this medicine last?
    The effect of Coversyl-AM 8/10 Tablet lasts for an average duration of approximately 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported for Coversyl-AM 8/10 Tablet.
  • Can this medicine be taken during pregnancy?
    Coversyl-AM 8/10 Tablet should not be used during pregnancy, since it may harm your unborn foetus, especially during the second and third trimesters. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Inform your doctor if you breastfeeding as Coversyl-AM 8/10 Tablet is not advised for breastfeeding women. According to some human research, this medicine passes into the breastmilk in small amounts which may harm your baby, especially if your baby is a newborn or was delivered prematurely. Consult your doctor for a safer alternative.

Allergy

Avoid taking Coversyl-AM 8/10 Tablet if you are allergic to Amlodipine and Perindopril. This could lead to symptoms like redness, swelling, breathing difficulties, hives, etc. You should ask your doctor for another alternative if you have a history of allergy to this medicine.

Angioedema

Angioedema is an allergic condition in which there is painless swelling under the skin mostly seen around the face and lips. Coversyl-AM 8/10 Tablet is not recommended for use if you have a known history of angioedema as it may worsen your condition.

Aliskiren

Aliskiren is a medicine used to reduce high blood pressure. Do not use Coversyl-AM 8/10 Tablet if you are taking aliskiren. Concomitant use of these medicines may lead to serious side effects such as low blood pressure, and high potassium levels in your blood. The risk is higher if you have a kidney problem or diabetes (high blood sugar level).

Sacubitril

Sacubitril is a medicine used in the treatment of chronic heart failure. It is recommended that you should not take Coversyl-AM 8/10 Tablet within 36 hours before or after taking a medicine that contains sacubitril as it may cause angioedema (swelling of the face, eye, lips, etc.).
Warnings for special population

Pregnancy

Coversyl-AM 8/10 Tablet should not be used during pregnancy, since it may harm your unborn foetus, especially during the second and third trimesters. Consult your doctor if you are pregnant.

Breast-feeding

Inform your doctor if you breastfeeding as Coversyl-AM 8/10 Tablet is not advised for breastfeeding women. According to some human research, this medicine passes into the breastmilk in small amounts which may harm your baby, especially if your baby is a newborn or was delivered prematurely. Consult your doctor for a safer alternative.
General warnings

Hypotension

Hypotension refers to a decrease in blood pressure. Coversyl-AM 8/10 Tablet may cause hypotension, especially when used in combination with other high blood pressure medicines and if you have low sodium levels in your blood. During therapy with this medication, you should check your blood pressure regularly. Depending on your clinical condition, your doctor may make appropriate dose changes.

Kidney diseases

Coversyl-AM 8/10 Tablet should be used with caution if you have a history of kidney problems. This medicine is excreted via the kidney and its metabolites may get accumulated in your body if there is kidney impairment.

Liver diseases

Coversyl-AM 8/10 Tablet should be used with caution if you have a history of liver problems due to the increased risk of liver failure. Get your liver function tests regularly done while you are on this medication. Inform your doctor if you develop any symptoms of jaundice increased level of bilirubin, a blood pigment that leads to yellow skin discolouration.

Driving and operating machines

Coversyl-AM 8/10 Tablet may affect your driving ability as it can lead to dizziness or weakness due to low blood pressure. After taking this medication, avoid performing activities that require high mental alertness such as driving vehicles or operating machines.

Missed Dose

If you forgot to take the dose of Coversyl-AM 8/10 Tablet at a given time, then take it as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Never take more than the prescribed dose of Coversyl-AM 8/10 Tablet. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Allopurinol

Carbamazepine

Dexamethasone

Itraconazole

Rifampicin

Insulin

Diclofenac

Candesartan

Disease interactions

Bone marrow suppression

Bone marrow suppression is a condition in which your bone marrow (a substance found in the bone that produces blood cells) activity is reduced which further leads to a decrease in blood cell count. If you are diagnosed with such a condition, take Coversyl-AM 8/10 Tablet with caution. This medicine causes bone marrow suppression and the risk is high if you have kidney impairment. This medicine cause bone marrow suppression and the risk is high if you have kidney impairment.

Congestive heart failure

Congestive heart failure (CHF) is a condition in which the heart is unable to pump blood efficiently. Take caution if you are having severe CHF. If Coversyl-AM 8/10 Tablet is taken in such conditions, it can lead to serious effects on your kidney which may lead to oliguria (low urine output) and kidney failure. Close monitoring of your kidney and heart condition may be necessary.

Hemodaialysis

Hemodialysis is a treatment in which a machine is used to filter the waste from the blood when the kidney fails to do so. If you are undergoing hemodialysis, take Coversyl-AM 8/10 Tablet with caution. This medicine may lead to anaphylactoid reactions (life-threatening allergic reactions) in such conditions.

Hyperkalemia

Coversyl-AM 8/10 Tablet may significantly increase the potassium levels in your blood (hyperkalemia). This may cause serious adverse effects such as irregular heartbeats. Report any unusual symptoms to the doctor immediately. Avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) while taking medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on your clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with Coversyl-AM 8/10 Tablet as grapefruit juice can increase the level of this medicine in your blood. This could lead to excessive lowering of blood pressure or worsen side effects such as dizziness, headache, swelling of hands and feet, etc.
It is recommended to avoid a high potassium diet during treatment with Coversyl-AM 8/10 Tablet due to the increased risk of serious side effects. Unless recommended by your doctor, do not take salt substitutes or potassium supplements while taking this medicine. Your doctor/dietitian will suggest an appropriate diet for you to avoid a high intake of potassium.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Coversyl-AM 8/10 Tablet before your meal or as advised by your doctor. Avoid taking a higher dosage than the dose prescribed by your doctor as it can lead to complications. If you experience any side effects, consult your doctor immediately. You should not stop the medicine abruptly as it can cause withdrawal symptoms. Therefore, it is important to complete your course of treatment. This medicine may cause dizziness in the first few days, so get up carefully if you've been sitting or lying down. You can also take it before bedtime to avoid dizziness during the day. Inform your doctor if you have a persistent cough or throat irritation. It may raise the potassium level in your blood. Avoid potassium supplements as well as potassium-rich meals like bananas and broccoli.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Coversyl-AM 8/10 Tablet contains Amlodipine and Perindopril which act together to relax your blood vessels thus, controls your blood pressure. Amlodipine relaxes your heart muscles and blood vessels. Perindopril relaxes your blood vessels and promotes the smooth flow of blood.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

ACE inhibitors with calcium channel blocking agents

Schedule

Schedule H

Dailymed.nlm.nih.gov. 2021. These highlights do not include all the information needed to use AMLODIPINE BESYLATE TABLETS safely and effectively. See full prescribing information for AMLODIPINE BESYLATE TABLETS. AMLODIPINE BESYLATE Tablets for oral administration Initial U.S. Approval: 1992. [online] Available at: < [Accessed 14 July 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1cec7a02-b7a5-49e1-ab64-3a4dab4149d2>

Medicines.org.uk. 2021. Amlodipine 10 mg tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 14 July 2021].

https://www.medicines.org.uk/emc/medicine/24889>

Drugs, H., 2021. Amlodipine: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 14 July 2021].

https://medlineplus.gov/druginfo/meds/a692044.html>

Medicines.org.uk. 2021. Perindopril Erbumine 4 mg tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 4 August 2021].

https://www.medicines.org.uk/emc/product/4390/smpc#gref>

Drugs, H., 2021. Perindopril: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 4 August 2021].

https://medlineplus.gov/druginfo/meds/a602017.html>

Dailymed.nlm.nih.gov. 2021. DailyMed - PERINDOPRIL ERBUMINE tablet. [online] Available at: < [Accessed 4 August 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fcaefca9-e6ca-4c97-9eb8-7f1c619ce4d0>
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Information on this page was last updated on 6 Oct 2021

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