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Working of SSRI medication for OCD
Sir, I was taking Fluxotine 20mg for last 7 years. Right now I am taking Fluxotine 30 MG due to increase in ego-dystonic thought. I was learning about how SSRI medication works. It will inhibit the Reuptake of Seretonin by the pre-synaptic cleft by blocking the receptor which is responsible for re-absorption of Seretonin. So, in turn level of Seretonin will be increased in the Synaps. But my question is , how that will help in preventing obsessive thought and compulsion ? I was reading a hypothesis that thalamas sends the report to pre-frontal cortex when a task is completed. But in case of OCD patient thalamas is unable to send the completion report to cortex, which in turn cause repititive action. So, my assumption is that path will be free with the increased level of Seretonin. So that Thalamas sends correct report to Pre frontal cortex. Is my understanding correct ? Or SSRI works in a different way to prevent the obsession and compulsion. Please clarify in medical terms.
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If u r taking Fluoxetine 30mg which is less-dose for OCD, so please consult your psychiatrist to go up on that if u r still facing OC symptoms.
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Adequate doses are necessary to treat a condition
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The mechanism of action of SSRIs are effective in treating OCD (clomipramine, a non-selective serotonin reuptake inhibitor, and the selective serotonin reuptake inhibitors [SSRIs]: citalopram, fluoxetine, fluvoxamine, sertraline and paroxetine) has given rise to the hypothesis that deficient serotonin function is a key element in the pathophysiology of OCD. These drugs block serotonin reuptake by the pre-synaptic neuron, thereby increasing serotonin availability at post-synaptic receptors. The serotonin hypothesis is also supported by the observation that m-CPP (a metabolite of trazodone), which is a partial agonist at serotonin receptor types 1A, 1D and 2C, exacerbates OCD.
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Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.