Download FREE Practo app
Get ₹200 HealthCash
Side effects clozapine,amisulpride
My mother(60y) has iq of 10year girl & always very panic of something bad happens to her children like accident or injury.
She has a condition Having seizure like eye roll upwards with eye pain and blabbering nothing should happen to her children,
it happens every 4 days(will comeback to normal after 8hrs of eye roll and blabbering).will be normal for next few days,again this happens as cycle. She is treated for last 35years
Now taking
clozapine(100mg) amisulpride(200mg) Nexito(10mg)
Divacid er 250(stopped for last 3 months)
3yrs back when doctor stopped clozapine and divacid er. she was active for 15days straight but her aggression starts to grow and not sleeping well.so we again started clozapine and divacid
Now divacid is stopped for last 3m. Now when clozapine is increased to 200mg,the cycle is reduced to alternate days & dull all time,so reverted to 100mg
I'm thinking clozapine is the reason for seizure like behaviour with eye rolling up with eye pain,headache
Answers (4)
Get your queries answered instantly with Care AI FREE
20000+ health queries resolved in last month
You have mentioned most of the details, still the duration of seizure like activity?? need to be assessed,
Valproate has been stopped, sudden tapering of sodium valproate can give rise to seizure activity as it is anti epileptic along with mood stablizer effect too, clozapine is also associated with seizure like activity
In the particular case of your mother, medications with dose and duration need to be reviewed for better choice with least side effects
You must consult your doctor and discuss it,
Besides this, comorbity as HTN, DM, etc also need to be assessed if present
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Didn't find the answer you are looking for?
Talk to experienced psychiatrist online and get your health questions answered in just 5 minutes.
+198
"Hi there, I understand that seeking help can feel overwhelming, but you’ve already taken the first brave step. I can guide you with a clear treatment plan tailored just for you, so you can feel better and regain control over your life. You can reach me directly on WhatsApp for quick support on seven zero eight two zero two two zero six two."
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Hi,
Clozapine is known to cause seizure but usually at high doses (beyond 600mg/day). It's in your best interest if you consult a psychiatrist in person and discuss the same. They might decide to change clozapine to some other antipsychotic or might add an antiepileptic to prevent seizure with clozapine (other than valproate which is causing sedation in your case)
Next Steps
consult a psychiatrist in person
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Dr. Pavitra Shankar
Psychiatrist
5 yrs exp
New Delhi
From your description, your mother has long-standing mental health concerns along with seizure-like episodes (eye rolling, blabbering, confusion, recovery after a few hours). These episodes could be epileptic seizures, medication-related side effects, or part of her psychiatric illness. Clozapine in particular can lower seizure threshold, especially at higher doses. The pattern you noticed — worsening when Clozapine was increased to 200 mg — suggests this possibility. However, only proper clinical evaluation and tests (EEG, neurology review) can confirm.
Next Steps
Please consult her treating psychiatrist and a neurologist together. She may need an EEG/brain imaging to rule out seizures.
• Her medication plan (Clozapine, Amisulpride, Escitalopram, mood stabilizers like Valproate/Devacid ER) should be reviewed. Sometimes Clozapine requires an accompanying anti-seizure medicine if seizures occur.
• Never stop or restart medicines on your own — Clozapine and mood stabilizers must be tapered or adjusted only under medical supervision.
Health Tips
Keep a diary of her episodes: timing, duration, behaviour before and after, and any triggers. This will help doctors decide if they are true seizures or not.
• Ensure she takes her medicines at the same time daily and does not miss doses.
• Maintain good sleep routine and hydration — poor sleep can trigger both seizures and psychiatric relapses.
• If she has a prolonged seizure (not regaining normalcy within minutes), take her to the emergency department immediately.
Answered
Flag this answer
Let others know if this answer was helpful
Was this answer helpful?
YES
NO
Articles you may like
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
The question asked on this page is a free question. You can ask a free health question by downloading the Practo app.
Articles you may like
Tell us what's troubling you
Tell us what's troubling you
Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.