Chronic ITP

She has been diagnosed ITP 9 yrs back and she has received IVIG anti D.platelet transfusion but no respond .she is steroids dependent and all these years she is on and off steroids .I want to know weather RITUXIMB will be effective
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Doctor Answers (1) on Chronic ITP

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Sharath Kumar K N Mandya | General Physician
Hello rituximab reduces the number of B cells that contain CD20, it reduces the total number of cells that produce antibodies. This may include the antibodies that attach to platelets. There is also evidence that rituximab alters T cells, another type of white blood cell, and that this may be the reason rituximab raises the platelet count of some patients with ITP. The short-term response rate for rituximab is about 60%. About 25% of patients achieve a longer-term (5 year) rise in platelet count.To enhance the response, rituximab is sometimes used in combination with dexamethasone (similar to prednisone) in newly diagnosed patients. So it is not, 100% effective. Please talk to your doctor.
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