Hello Doctors, I am a 33yr old female. This is my second pregnancy. My NT scan was normal but triple marker test was positive with 1:182 ratio positive screening for Trisomy 21. The matter of concern for me is that the value of unconjugated estriol (uE3) is extremely low which is 0.13 ng/mL at 14 weeks 6days pregnancy also my Triple Marker was done twice by the lab to rule out any discrepancy. How reliable is Triple Marker also can it show false results as it was done at 14 weeks while it's suggested to get it done after 16 weeks. Also mentioning the MoM values for your reference AFP 0.79 Ue3 0.51 HCG 1.46 Kindly suggest does these MoM are too low/high or the pregnancy could be healthy with these values.