Undergo glutathione therapy.. otherwise few creams also available...for detailed prescription do direct online consultation by sending photos.

Sudden darkening of knuckles can be caused by several factors. High cortisol or B12 deficiency usually cause gradual, not sudden, pigmentation changes. Sudden darkening may suggest other causes like post-inflammatory changes or acanthosis nigricans. A proper evaluation with blood tests and skin examination is important. An online consult will help identify the cause and guide treatment. 🩺 – Dr. Silky Priya Consultant Dermatologist, Silky Skin Solutions, Pune Available for online consults via Practo

Based on the history and image shared looks like Acanthosis Need to do blood investigations for the same

Will improve with medication Need to do some blood work Consult online for further management

It can be treated kindly consult us online so that we can get your detailed history and prescribe you accordingly

Kindly consult online for further examination and proper treatment

Possible causes have to be ruled out

Need investigations

No need to worry.specific treatment is available.it depends on severity of the disease . Complete medical history is required.. Pls do online consultation with Dermatologist for detailed prescription & guidance.