Multiple myeloma

2021-10-24 13:24:39
On a routine test in June, my 59 y/o mother had slightly high serum globulins (4.7) and slightly high calcium (10.3) So we did the following tests :- 1- Serum protein electrophoresis - Came back normal with no M spike 2- Serum FLC - Kappa - 33.1 (Ref- 3.3 to 19.4) -  Slightly high Lambda - 18.1 - Normal Kappa/Lambda ratio - 1.83 (Ref- 0.26 to 1.65) Her calcium is back to normal now (without medications). At present, her calcium is 8.9, Hb is 12.5, serum globulin is 3, creatinine is 0.75, urea is 25 and x rays have shown arthiristis. So she doesn't have anemia, hypercalcemia, kidney damage or bone lesions, as of now. However, her kappa chains are elevated and kappa/lambda ratio is slightly high. What is it pointing towards ? Could it be multiple myeloma ?
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Answers (2)

No it cannot be multiple myeloma. You can have a discussion with your hematologist regarding elevated light chain essays. From the looks of it it seems to be MGUS which has very low rate of progression to myeloma m

Answered2021-10-24 13:28:39

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First of all you have compiled reports and history very well. This does not look multiple myeloma. Elevation of single kappa or lambda does not point out myeloma.
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you can repeat the same tests after 6 months

Answered2021-10-24 13:34:00

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