Key Clinical Summary:
Onset: 3 weeks ago after starting high-protein, dairy-rich diet (vegetarian)
Took Naproxen (NSAID)
Symptoms: Altered bowel habits (type 5–6 stools alternating with constipation)
Medication: Took Symbiolardi (probiotic) and Rifagut (rifaximin) for 2 weeks → improved
Current labs: Normal CBC,
CRP,
electrolytes; ESR mildly raised at 30
No major symptoms during Goa travel
Patient is anxious, appointment pending
📌 Differential Diagnosis (per Harrison’s guidelines):
1. Irritable Bowel Syndrome (IBS) – Mixed Type
Typical features:
Alternating bowel habits (constipation + loose stools)
No alarm symptoms (weight loss, blood in stool, nocturnal diarrhea)
Often precipitated by diet change, stress, or infection
Improvement with rifaximin + probiotic supports functional GI disorder
2. Post-Infectious IBS or Food Intolerance
Change in diet (increased dairy/protein) and possible NSAID-related gut flora disruption
Naproxen can cause enteritis or low-grade colitis
3. Non-Specific Colitis or Low-Grade Inflammation
Mildly elevated ESR can be non-specific or related to inflammation
Normal CRP, CBC make IBD unlikely
✅ Recommended Next Steps:
🔍 Clinical Workup:
Stool calprotectin or fecal lactoferrin (to rule out IBD vs IBS)
Food diary to track symptoms vs diet
If persistent: consider colonoscopy (if age >40, persistent symptoms, or family history)
💊 Symptomatic Management:
Continue probiotics
Use bulk-forming agents (psyllium) for stool consistency
Avoid excess dairy or protein isolates temporarily
🧘♀️ Lifestyle:
Hydration, physical activity
Low-FODMAP diet trial if symptoms persist
🟢 Favoring IBS Over Organic Pathology:
Normal blood work
Good response to rifaximin
No systemic symptoms
Tolerated travel food without worsening
📘 References:
Harrison’s Manual of Medicine, Irritable Bowel Syndrome: Symptoms include altered bowel habits with normal inflammatory markers.