What is IVF?
In vitro fertilization or as is commonly called as IVF or test tube babies. It is a procedure where fertilization of an egg or ovum is made to combine with sperm outside the body; essentially in a glass tube. The words "in vitro" refers to "in glass".
How much does IVF (In-Vitro Fertilization) cost?
The cost of IVF treatment depends upon some of the factors like:-
Following is the approximate cost of this procedure in Bangalore:
Minimum cost of Rs. 25,000
Average Cost of Rs.1,40,000
Maximum Cost of Rs.2,00,000
Is IVF (In-Vitro Fertilization) painful?
During IVF, the most sensitive step is to place the fertilized zygote back into the uterus. Patients may experience different levels of sensations. The definition of pain greatly depends on the degree of tolerance of the patient. Some may experience a slight sensation while others may narrate the same process as discomfort.
Is IVF (In-Vitro Fertilization) successful for infertility treatment?
IVF was discovered as assisted reproductive techniques for couples with difficult conception or infertility. The success rate depends on a variety of factors including Age, previous pregnancies, type of technique used, type of fertility problem, use of ova and the center of IVF.
What is the success rate for IVF (In-Vitro Fertilization) procedure?
Broadly, it is considered that the success rate is around 40% and is higher in younger couples. But it will vary between patients and will be affected by different factors such as the age of the eggs, type of infertility problem etc.
Why does IVF (In-Vitro Fertilization) fail?
Failure is a major concern in assisted reproductive techniques. The major factors involved are the age of the eggs, ovarian response, chromosomal issues, lifestyle factors, the degree of severity of infertility.
Are IVF (In-Vitro Fertilization) babies healthy?
The process is monitored under highly specialized and trained medical professionals and every care is taken to help the mother bear a normal child. However, 100% guarantee can never be given and unfortunate consequences including chromosomal abnormalities and pregnancy loss can happen.
Are there side effects of IVF (In-Vitro Fertilization)?
Side effects of infertility medication :
What is the difference between IVF and IUI?
Intrauterine insemination or IUI is the procedure where sperms processed and concentrated are transferred into the uterus directly for fertilization with the ovum.
In IVF the ovum/ ova and the sperms are fertilized outside the body in a glass tube.
Are there any success tips for IVF (In-Vitro Fertilization)?
Even though nothing guarantees the success of the IVF procedure, the following can augment the results :
Is IVF (In-Vitro Fertilization) covered by insurance?
IVF may or may not be covered under your insurance. It depends on what plan you take and from what company are you insured under.
What next if IVF (In-Vitro Fertilization) fails?
If the first cycle of IVF has failed, you may try for a second and a third attempt too.
Be vigilant and well informed about the procedure, risk factors and outcome rates.
Discuss with your doctor for reasons of failure in your case and avoid the same.
In vitro fertilization or as is commonly called as IVF or test tube babies. The words "in vitro" refers to "in glass". It is a procedure where an egg or ovum is made to combine with sperm outside the body or uterus; essentially in a glass tube. The procedure is an assisted reproductive technique to benefit infertile couples. Among all other techniques available, this has been the most effective one. IVF has various types and it is inevitable to determine the type of the IVF needed for a particular patient, its success rate and cost since the process is very expensive and time-consuming.
In vitro fertilization (IVF) is a technique to treat genetic or infertility problems.
For Infertility issues; the doctor may advise the couple to undertake less invasive means before attempting IVF. This may include fertility drugs, Intrauterine Insemination.
However, this is not a set guideline for attempting for non-invasive methods before IVF.
IVF may be directly advised in following health conditions as well :
The inclusion and exclusion criteria depend on area/country of treatment and the guidelines the specific area follows for offering treatment. For example- United Kingdom follows National Institute for health and care excellence guidelines, also known as NICE guidelines.
An ideal candidate for an IVF trial depends upon the following factors:
Following may be discouraged for attempting IVF as a mode of conception:
Your doctor will hold an affiliated degree of specialization in Obstetrics and Gynaecology. Further, the doctor might have done a fellowship in In vitro Fertilisation techniques and may have an experience in handling infertility patients.
In Vitro fertilization isn’t an easy choice to be made for conception purpose. The results are never guaranteed and is highly expensive.
It is advised to consider and understand the following in detail before deciding to attempt IVF:
Preparing for IVF using your own sperms and eggs:
Your doctor may ask you to undergo a screening test, including the following :
The couple should inquisitive and should understand the steps of the procedures along with techniques involved.
Following will be useful :
How many embryos will be transferred?
How will extra embryos be used?
IVF & CryopreservationHow will you handle a multiple pregnancy?
The risks associated with carrying IVF through a donor (whether donating eggs, sperm or embryos) or a gestational carrier?
In vitro fertilization (IVF) is a multistep procedure involving several steps as mentioned below:
This step involves treatment with artificial or synthetic hormones to help your ovaries produce more ova or eggs. This is done as some eggs don’t fertilize and develop after fertilization.
To assist the same following can be done :
Approximately 36 hours after the final injection, egg retrieval is carried out. It is taken care that it is done prior to ovulation. The patient is given sedation and analgesics (pain medication).
Following methods are used for egg retrieval:
The eggs retrieved are then put in a culture medium (nutritive liquid) and are incubated. They are then made to fertilize with sperm to form embryos.
Following methods can be used to retrieve semen sample:
After the sample collection, sperms are separated from semen fluid.
Fertilization can be done using two common methods:
Other procedures before embryo transfer:
Assisted hatching- On 5th or 6th day after fertilization, an embryo hatches from its membranes called ‘zona pellucida’ and is ready for implantation. In cases of elderly women or multiple failed IVF, the hatching is assisted to increase the chance for growth post transfer into the uterus.
Preimplantation genetic testing - This is done to check for specific genetic diseases, number of chromosomes and chromosomal abnormalities. The embryo is made to incubate before it is transferred. A small sample is then retrieved and tested for the diseases.
This is done 2 to 6 weeks after egg retrieval. It is done under mild sedation and is a painless procedure. It takes around 2 weeks for a single IVF cycle to be completed. Also as per the medical condition diagnosed and the outcome of the previous cycle, more than one cycle may be required.
Embryo transfer is the last step for the IVF procedure. After the transfer, the couple can resume normal activities. The ovaries are still bulky and the female is advised to restrain strenuous activities like exercise or lifting heavy weights.
Following are few effects the female partner may notice after the embryo transfer :
IVF as a technique is expected to help the couple become parents with a healthy baby without any side effects. But the idea of creating test tube babies or for that matter having any technique to assist the reproduction has always been a controversial issue. The following are few facts put forward by clinicians and renowned experts in the field of IVF, but these are still debatable:
Deranged clotting factors: The fact that IVF technique use and results in high estrogen levels in the body, it can result in increased risk of blood clots
There is a great chance that IVF babies may have a preterm delivery.
Pre-eclampsia- the term refers to an increase in blood pressure during pregnancy. There is a higher chance of mothers developing this. Such mothers are at risk of having cardiovascular disease later in life.
Stress and depression- this is seen higher in cases with failed IVF procedure.
Studies have also shown that babies born through IVF are at a higher risk of having birth defects.
The success of IVF depends on a variety of factors mentioned above. Though research does not mark a number and guarantee success through IVF, it is believed that assisted reproductive techniques have a success of around 40%.
IVF is offered as a multiple cycle approach and so failure in a single attempt isn’t considered as a failed IVF. Couples may opt for the following in cases of failed IVF attempts:
Gestational surrogacy and traditional surrogacy
In Vitro Fertilisation is one of the assisted reproductive techniques. Couples may try for the following procedures as well.
These include :