Synaptophysin is a calcium-binding protein present in the presynaptic vesicles of neurons as well as vesicles in the neuroendocrine cells. Synaptophysin is expressed in neuronal tumors and tumors with neuroendocrine differentiation including neuroblastoma, ganglioneuroblastoma, ganglioneuroma, pheochromocytoma/paraganglioma and carcinoid/neuroendocrine carcinoma. Antibodies to synaptophysin strongly stain the cytoplasm of all the neuroendocrine cells in the pancreatic islets and is also seen in adrenal cortical cells, probably due to a closely related protein. Synaptophysin is an integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. This antibody reacts with a hydrophilic peptide sequence selected from the deduced amino acid sequence of synaptophysin.
No special preparation is needed for Synaptophysin Immunohistochemistry Biopsy Tissue. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Synaptophysin Immunohistochemistry Biopsy Tissue. Your doctor depending on your condition will give specific instructions.
|All age groups
|A positive staining is seen in case of detection of Neuroendocrine Tumors