Antibody tests are blood tests that determine specific antibodies which simplify the diagnosis of lupus, Antinuclear antibody (ANA) Anti-RNP. Anti-Smith (Sm),.Anti-Smith antibodies are present in some cases of systemic lupus erythematosus (SLE) and mixed connective-tissue disease (MCTD). Smith antigens are elements of the extractable nuclear antigens (ENAs); typically they are the proteins that are resistant to ribonuclease.
It can also be useful in confirming a diagnosis of systemic lupus. Contrasting anti-dsDNA, anti-Sm does not associate with the presence of kidney lupus. They are connected with central nervous system involvement, kidney disease, lung fibrosis and pericarditis in SLE, but they are not related with disease activity.
The presence of Smith antibody is specific for systemic lupus erythematosus (SLE), but occurs only in 30-35% of patients with SLE. The Smith and related nuclear ribonucleoproteins are targets for the autoantibodies developed by patients with SLE.
Inform your doctor if you are on any medications, have any allergies or underlying medical conditions before your SM Antibody. Your doctor will give specific instructions depending on your condition on how to prepare for SM Antibody.
No Preparation is required.
|All age groups
|Smith Antibodies detected in positive cases