The p63 protein is a member of the p53 family of tumor-suppressor proteins. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63. While some targeted agents should not be used in squamous cell carcinomas, other agents might preferably target SCCs. In a previous microarray study, one of the top differentially expressed genes between adenocarcinomas (ACs) and SCCs is P63. It is a well-known marker of squamous differentiation, but surprisingly, its expression is not widely used for this purpose. Our goals in this study were to further confirm our microarray data, to analize the value of P63 immunohistochemistry (IHC) in reducing the number of large cell carcinoma (LCC) diagnoses in surgical specimens, and to investigate the potential of P63 IHC to minimize the proportion of
No special preparation is needed for P 63 Immunohistochemistry Biopsy Tissue. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing P 63 Immunohistochemistry Biopsy Tissue. Your doctor depending on your condition will give specific instructions.
|UNISEX||All age groups||A positive staining is seen in case of detection of Squamous Cell Carcinoma|