Lipid Profile With Apolipo Blood

Lipid profile Apolipoprotein blood test is used to measure the levels of lipids and apolipoproteins in the blood. This test helps in estimating the risk of cardiovascular diseases.

Test parameters:

• HDL (High-density lipoproteins)
• LDL (Low-density lipoproteins)
• VLDL (Very low-density lipoproteins)
• Total cholesterol
• Triglycerides
• Apolipoprotein A1
• Apolipoprotein B

What is the importance of lipids and apolipoproteins?

Lipids are a bunch of fats and fat-like substances which are very useful constituents of the cells in our body. They are also an important source of energy. Cholesterol and triglycerides are the two important lipids. Cholesterol and triglycerides are transported are circulated into the blood through lipoprotein particles. Each lipoprotein particle is a combination of cholesterol, phospholipids, triglycerides and protein molecules. They are classified based on their density into three types. They are:

• HDL (High-density lipoproteins)
• LDL (Low-density lipoproteins)
• VLDL (Very low-density lipoproteins)
• Total cholesterol
• Triglycerides
• Apolipoprotein A1
• Apolipoprotein B

High-density lipoproteins (HDL) are considered as good cholesterol and low-density lipoproteins (LDL) is considered as bad cholesterol. High-density cholesterol carries cholesterol to the liver from various parts of your body. Liver functions by eliminating the cholesterol out of the body. HDL helps in moving the cholesterol away from your arteries. The increased amount of HDL helps in reducing the risk of coronary heart disease. LDL gets attached to the walls of arteries and clogs them. This leads to a condition called atherosclerosis. Total cholesterol is the sum of both HDL and LDL. With the help of total cholesterol and HDL values, total cholesterol-to-HDL ratio can be derived with which coronary heart disease and stroke can be diagnosed.

Apolipoprotein A1 is a type of protein which is carried by HDL. This helps in the process of removing bad types of cholesterol from the body. Thus the excess cholesterol can be removed and it helps in preventing cardiovascular diseases.

Aloplipoprotein B is the main component of LDL. High levels of it can damage heart and arteries because LDL is considered as bad cholesterol.

Why is this test performed?

This test is done to know whether an individual is having normal or abnormal cholesterol levels in the body. The doctor may ask to perform this test if an individual is suffering from conditions like diabetes, high blood pressure and have heart disease or with a family history of heart disease, have a heart attack. This test is also done to determine the risk of developing heart disease. If an individual is on the treatment of anti-cholesterol medications like statins, then the doctor may ask to perform this test to evaluate and to check the effectiveness of the treatment and cholesterol levels in the body. This helps the doctor to rule out the patient disease condition. Generally, when a patient is diagnosed with atherosclerosis or hypercholesterolemia visits hospital for a general check-up, the doctor may ask to undergo the lipid profile test which gives a better status of the condition. Mostly, this test is done along with other tests like an electrocardiogram (ECG), echocardiogram, cardiac catheterization.

Precautions:

Smoking and medicines like statins (simvastatin, rosuvastatin) may change the levels of lipids in the blood. Hence inform your doctor or technician about all your current medications and medical conditions prior to the test.

The normal reference range may vary depending on gender, age, health history, etc.

If HDL blood levels are more than the normal range, then it may indicate that there is a very low chance for risk of developing heart disease. If test results are less than the normal range, then it indicates that there may be a chance for risk of developing heart disease.

If LDL blood levels are more than the normal range, then it may indicate that there is a high chance of risk for developing a heart disease and other conditions like heart attack (blockage of blood flow to the heart muscle), atherosclerosis (deposition of fat, cholesterol and other substances in the artery walls), blockage of blood flow due to fat deposition in the arteries, obesity, high consumption of fatty food items, smoking, less physical activity etc.

If VLDL blood levels are more than the normal range, then it may indicate that there is a high chance of risk for developing a heart disease and other conditions like heart attack (blockage of blood flow to the heart muscle), atherosclerosis (deposition of fat, cholesterol and other substances in the artery walls), blockage of blood flow due to fat deposition in the arteries, obesity, high consumption of fatty food items, smoking, less physical activity etc.

If your total cholesterol blood levels are higher than the normal, range then it may indicate that there is a low chance for risk of developing a heart disease, good physical activity, infection, inflammation, cirrhosis (liver damage and causes liver failure), inherited lipoprotein deficiency (genetic disorder in which a person does not have the lipoprotein lipase enzyme which helps to break down the fat molecules).

If your apolipoproteinA1 levels are high it may be due to familial hyperalphalipoproteinemia, a type of genetic disorder. Low levels of it may be due to familial hypoalphalipoproteinemia, Tangier disease another type of genetic disorder, nephrotic syndrome (kidney problems), kidney failure, coronary artery disease, cholestasis (a type of bile disorder), hepatocellular disorders (liver problems), etc.

If your apolipoprotein B levels are high it may indicate risk of getting cardiovascular disease.

If you get abnormal test results does not always mean you have a medical condition. Consult your doctor with your test results. Your doctor may recommend other tests depending on your results.