|

Practo

Diagnostic Tests

Jak 2 V617F Common Mutation Pcr Bone Marrow

image

Jak 2 V617F Common Mutation Pcr Bone Marrow

What is this test?

The Janus kinase 2 gene (JAK2) codes for a tyrosine kinase (JAK2) that is associated with the cytoplasmic portion of a variety of transmembrane cytokine and growth factor receptors important for signal transduction in hematopoietic cells. Signaling via JAK2 activation causes phosphorylation of downstream signal transducers and activators of transcription (STAT) proteins (eg, STAT5) ultimately leading to cell growth and differentiation. BCR-ABL1-negative myeloproliferative neoplasms (MPN) frequently harbor an acquired single nucleotide mutation in JAK2 characterized as c.G1849T; p. Val617Phe (V617F). This mutation is identified overall in approximately two-thirds of all MPN,(1-3) but the prevalence varies by MPN subtype. The JAK2 V617F is present in 95% to 98% of polycythemia vera, 50% to 60% of primary myelofibrosis (PMF), and 50% to 60% of essential thrombocythemia (ET). It has also been described infrequently in other myeloid neoplasms, including chronic myelomonocytic leukemia and myelodysplastic syndrome.(4) This mutation is not seen in chronic myelogenous leukemia (CML) or in reactive conditions with elevated blood counts. Detection of the JAK2V617F is useful to help establish the diagnosis of MPN. However, a negative JAK2 V617F result does not indicate absence of a MPN. Other important molecular markers in BCR-ABL1-negative MPN include CALRexon 9 mutation (20%-30% of PMF and ET) and MPL exon 10 mutation (5%-10% of PMF and 3%-5% of ET). Mutations in JAK2, CALR, and MPL are essentially mutually exclusive.

Test Preparation

No special preparation is needed for Jak 2 V617F Common Mutation Pcr Bone Marrow. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Jak 2 V617F Common Mutation Pcr Bone Marrow. Your doctor depending on your condition will give specific instructions.

Understanding your test results

GenderAge groupsValue
UNISEXAll age groupsMutation is seen in positive cases
Your Cart0 Tests
Proceed to Checkout

Popular Health Packages

Comprehensive Young Indian Health Checkup

Ideal for individuals aged 21 - 40 years

Includes 88 tests

T3-T4-TSH
Iron Deficiency Profile
Liver Function Tests

Young Indian Health Checkup

Ideal for individuals aged 21 - 40 years

Includes 60 tests

T3-T4-TSH
Iron Deficiency Profile
Liver Function Tests

Active Professional Health Checkup

Ideal for individuals aged 41 - 60 years

Includes 76 tests

TESTOSTERONE
AMYLASE
LIPASE

Comprehensive Active Professional Health Checkup

Ideal for individuals aged 41 - 60 years

Includes 83 tests

HOMOCYSTEINE
25 - OH VITAMIN D (TOTAL)
VITAMIN A

Advanced Young Indian Health Checkup

Ideal for individuals aged 21 - 40 years

Includes 63 tests

TESTOSTERONE
HbA1c
Hemogram - 6 Part (Diff)

Working Women's Health Checkup

Ideal for individuals aged 21 - 40 years

Includes 67 tests

FOLLICLE STIMULATING HORMONE (FSH)
LUTEINISING HORMONE (LH)
PROLACTIN (PRL)

Our happy customers

Very professional phlebo. Excellent job in collecting the sample. No pain at all. Got my report also within 24 hours.
Malathi Ganapathy, 62
On 25th October 2018
Everything went very well and smoothly. Technician was right on time. Really happy with the service.
Ashish Garnaik, 30
On 23rd November 2018
Good service, Practo is avoiding to stand in que for health checkup.
Lalita Hegde, 64
On 21st September 2018
We serve in
Bangalore, Hyderabad, Chennai, Mumbai, Delhi, Pune, Kolkata, Navi Mumbai, Thane,  Gurgaon, Noida, Ahmedabad, Chandigarh, Ghaziabad, Indore, Jaipur, Lucknow,  Patna, Ernakulam, Bhubaneswar and Coimbatore.