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Practo

Diagnostic Tests

Islet Cell Antigen 512 Antibodies

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Islet Cell Antigen 512 Antibodies

Also known as Islet Cell Antigen 512 Antibodies Elisa Blood
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What is this test?

Islet cell antigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with the secretory granules of neuroendocrine cells. ICA-512 is also known as protein tyrosine phosphatase-IA2 (PTP-IA2) or tyrosine phosphatase (IA2). It is an autoantigen of type 1 diabetes. This is NOT the same as pancreatic islet cell. Studies on type-1 diabetic patient’s relatives found that the development of one or more islet autoantibodies (including IA-2 antibody) was an early indicator of the relatives’ progression to type-1 diabetes. Autoantibody profiles identifying patients destined to develop type-1 diabetes are usually detectable before age three. One study found that for relatives seropositive for IA-2 antibody, the likelihood of developing type-1 diabetes mellitus within five-years was 65.3%. Some type-1 diabetic patients are originally diagnosed as having type-2 diabetes due to symptom onset in adulthood, societal obesity, and initial insulin-independence. Detection of one or more islet auto-antibodies (including IA-2) may be used to distinguish these patients with "latent autoimmune diabetes" from type-2 diabetics.

Test Preparation

No special preparation is needed for Islet Cell Antigen 512 Antibodies. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Islet Cell Antigen 512 Antibodies. Your doctor depending on your condition will give specific instructions.

Understanding your test results

GenderAge groupsValue
UNISEXAll age groupsThe antibodies are not normally present. Antibodies detected in autoimmune type 1 diabetes
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