For the diagnosis and monitoring of gastrin-secreting tumors, gastric ulcer, Zollinger-Ellison syndrome. Increased in pernicious anemia. Gastrin is secreted by antral G cells and stimulates gastric acid production, antral motility, and secretion of pepsin and intrinsic factor. The principle forms of gastrin in blood are G-34 (big gastrin, half-life is five minutes) and G-14 (minigastrin, half-life is five minutes). Each of these polypeptides circulates in nonsulfated (I) or sulfated (II) forms. Instilling acid into the stomach normally inhibits gastrin secretion. Elevated gastrin levels should be interpreted in light of gastric acid secretion and other parameters. The neuroendocrine tumors associated with the Zollinger-Ellison syndrome are characterized by elevated rates of gastric HCl secretion and upper gastrointestinal ulcer disease. Gastrin levels >500-600 pg/mL in a patient with basal acid hypersecretion often indicate gastrinoma, but antral G-cell hyperplasia cases can have gastrin levels >500 pg/mL and hyperchlorhydria. If gastrinoma is likely but fasting gastrin level is not diagnostic, the secretin test is the provocative test of choice. Absolute increase in serum gastrin level above the basal figure is preferred to percent change.4 I.V. secretin normally diminishes gastrin, but serum gastrin increases in gastrinoma patients. Wolfe provides an explanation for this paradoxical effect.4 Calcium infusion also stimulates gastrin release but does not distinguish other causes of ulcer as well as the secretin test. Protocols for stimulation tests are published. No consistent relationship has been established between Helicobacter pylori (Campylobacter pylori) and gastric acid secretion or serum gastrin levels. Features of gastrinoma additional to those of peptic ulcer may include diarrhea and steatorrhea. Gastrinomas are usually found in the pancreas but they may be primary in the duodenum. A few cases in which a gastrinoma was primary in the stomach have been reported.
No special preparation is needed for Gastrin (Post Prandial) Immunoassay Blood Serum. Inform your doctor if you are on any medications or have any underlying medical conditions or allergies before undergoing Gastrin (Post Prandial) Immunoassay Blood Serum. Your doctor depending on your condition will give specific instructions.